🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Only a few more days to apply for this post doc position in our team to work on #phages. Please get your applications in through the official Otago Taleo website.

Congrats Patrick! Excited to hear more about what you’re tackling. Expecting big (!) findings here 🎉

Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from viral groups that were so far mostly terra incognita - and all infect the E. coli K12 lab strain with easy tricks. 1/12 tinyurl.com/3xdt65f5

Microbiomes shape the health of our bodies and our planet. By editing the #microbiome, can we intervene for a healthier future? Learn more about our audacious initiative from PIs Brady Cress, Spencer Diamond, and Ben Rubin! Watch the video here: youtu.be/306hUEMG3Ow

I'm excited to share the 1st preprint from Rubin Lab, co-led by Leo Song and I. We performed RB-TnSeq to identify host genes important for CRISPR-associated transposon (CAST) integration. The screen was leveraged to improve CAST editing in bacteria. biorxiv.org/content/10.110…

The manuscript is the result of a collaborative effort in a new lab. Thanks to all involved: Agnès Oromí-Bosch Sophia Swartz Jon Martinson Jigyasa Arora Abby Wang Rachel Rovinsky Sara Smith Emily Weiss @Deutschbauer_Lab Doudna Lab Brady Cress Cress Lab Ben Rubin

Very excited to share this work identifying host factors crucial for type I-F CRISPR-associated transpose integration co-led by me and Amanda Alker. Much thanks to all the amazing co-authors, collaborators, and funders who made this project possible! Rubin Lab Innovative Genomics Institute

(image credits, of course, to Brady Cress)

An experimental census of retrons, now published in Nature Biotechnology. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. nature.com/articles/s4158…

Happy Postdoc Appreciation Week! 🎉 Shoutout to our fantastic postdoc Jaymin and our incredible staff scientist Agnès (our honorary postdoc because she’s that amazing—and we couldn’t agree more!).

Cyanobacteria in space! New paper from Spencer Diamond: Desiccated Cyanobacteria Serve As Efficient Plasmid DNA Carriers in Space Flight | ACS Synthetic Biology doi.org/10.1021/acssyn…

#weekendreading🦠👇 Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens Cell cell.com/cell/fulltext/…

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

🚨 New preprint alert! I am excited to present a collaboration between the Doudna Lab and Zev Bryant lab, with co-first authors Noor Al-Sayyad and Kevin Wasko and me. Curious about what drives high-efficiency genome editing by Cas9? Let’s dive in!👇🧵biorxiv.org/content/10.110…

If you work with metagenomes (or metatranscriptomes), would like to explore what viruses/phages are in your datasets, but don't know where to start, we have (an) MVP for you now \o/ Really happy to see this one published, and also welcoming feedback/suggestion of improvement!

Some partnerships are always fun!! Excited to share one such 🎉 product w Simon Roux perspectives on our favorite “atypical” phages, for special issue to celebrate my former mentor Carol Gross UC San Francisco Tapping the treasure trove of atypical phages sciencedirect.com/science/articl…

Congrats to Raphael Hofmann for his work that combined with deep mutational scanning of Cas1 and Cas2 with a high throughput spacer acquisition assay to make this process more efficient. Thanks to Calvin Charlie Mo and Jacob Mathai for their help! biorxiv.org/content/10.110…

Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts dlvr.it/TFG6L5

Thanks for the invitation Tae Seok Moon! It was fun to present and to chat with you and Lindsay.