*Ten* 3-year post-doc/assistant prof jobs advertised for our Pioneer Centre for SMARTbiomed - address key questions in common complex diseases through development of new stat/comp tools & software. A new Denmark-Oxford collaboration. Critical mass! smartbiomed.dk/join-the-centr…

Extremely clever new NGS tech from Roche 🧬 If it's hard to discriminate between nucleic acids accurately with a nanopore, why not synthesize a new polymer off a DNA template that is easier to sequence? It's an intuitively simple idea, but took *a ton* of creative nucleic acid

Cool! But 'so long' to detecting DNA modifications?

Great course!

Really cool to see this building on concepts introduced by Cytocipher and SC-SHC. Looks like a really elegant solution that takes into account resolution up- and down- cell hierarchy, and also options to account for potential batch effects internally.

Our preprint on designing and editing cis-regulatory elements using Ledidi is out! Ledidi turns *any* ML model (or set of models) into edit designers! Now, you can easily find minimal sets of edits to DNA sequences that induce desired characteristics.

A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in Cell and available to import through The Jackson Laboratory sciencedirect.com/science/articl…

Please check out our new manuscript extending the GREML methodology to quantify assortative mating and other forms of trait-associated genetic structures. Thanks to all our co-authors and the study participants! Here: nature.com/articles/s4158…

Pangenome-aware DeepVariant biorxiv.org/content/10.110…