Catch Chenzhen Zhang’s Saturday (3:30PM Monet Room) talk Orthopaedic Research Society on cartilage drug delivery exosomes and @BME_Tim’s Poster #600 on cartilage-targeting peptides from 10AM-11:30AM!

Don’t miss our wonderful PI giving a talk in the 3:15-4:15PM (Chantilly West) drug delivery session tomorrow Orthopaedic Research Society #ORS2023 in Dallas Northeastern University Bioengineering

Tim Boyer and Tanvi Vinod Pathrikar, Department of Bioengineering PhD students, each participated in and won the Northeastern COE PhD Research Expo for the best poster presentations. Tim and Tanvi are both a part of Bajpayee Lab

Curious about CT imaging for cartilage? Check out our new publication in ACS Nano exploring cationic cartilage-targeting contrast agents used in low-doses! pubs.acs.org/doi/10.1021/ac… Chenzhen Zhang Armin Vedadghavami Tengfei

Last week we got to congratulate Dr. Chenzhen Zhang on completing his Ph.D. Chenzhen Zhang has built the foundation for multiple new research directions in our lab and has been an invaluable asset to 7 new Ph.D. students!

Check out our new exciting work, showing we can deliver therapeutics into cartilage with simple and safe positively-charged peptides and proteins!

Tanvi’s award-winning research using a new therapeutic approach to combat osteoarthritis was selected by SFBiomaterials for an Online Talk this Wednesday 12/6 at 12PM. Join Virtually here: bit.ly/3Fy3IuU (Free Registration)!

We are delighted to share our new publication on oral delivery using surface-modified milk exosomes for  siRNA delivery to the GI tract with ionic interactions. Biomaterials Science. Link: doi.org/10.1039/D3BM01… Congrats to Hengli Zhang & Chenzhen Zhang  who spearheaded this project!

Happy to share that our recent work was selected by Biomaterials Science to be featured as cover art! Here we develop mucus penetrating milk exosomes for oral gene delivery! Link: xlink.rsc.org/?DOI=D3BM01089A

We are super excited to head back to #ORS2024 this year! Come stop by our posters and talks on #ElectrostaticDrugDelivery! Orthopaedic Research Society ORS Spine Section Northeastern University Bioengineering

Great talks by Helna and Tim on #ElectrostaticDrugDelivery! Thank you Orthopaedic Research Society for hosting us! Now excited to continue the work! Northeastern University Bioengineering Ambika Bajpayee

Excited to share our new method preprint, WISH-BONE, to label osteocyte mRNA and protein in 3D mouse bone, presented at #ORS2024. Collaboration between ShefelbineLab, Monaghan Lab, and LifeCanvas Technologies. Stay tuned for videos! biorxiv.org/content/10.110… Orthopaedic Research Society, Northeastern University Bioengineering

Excited to share our recently published work on synthesizing charge-reversed cationic exosomes which demonstrates superior transport, retention, and mRNA delivery to the deep layers of cartilage tissue. Open Access #SmallMethods. rb.gy/i1bbxm Cred Chenzhen Zhang et al!

Thank you to co-chairs Ambika Bajpayee @ANKoppes, planning committee, and students for Northeast SFBiomaterials Symposium Northeastern University Bioengineering. Bajpayee lab members were busy! (1/n)

I am excited to share my recent PhD research with a podium presentation on Saturday and chat with prospective Post-Doc Advisors! Come chat with me at my Future Post-Doc Poster! Orthopaedic Research Society #ORS2025. Bajpayee Lab

🚀 New preprint from the Shefelbine Lab! doi.org/10.1101/2025.0… 🦴Yoda2 + tibia loading combination enhance mechanoadaptation in 22-month-old mouse bones. Preliminary in vivo calcium imaging suggests Yoda2 reaches osteocytes in old mouse bones @ORS2025 2/8, 4:15pm North 221

We are thrilled to share our latest work on surface-engineered exosomes for sustained interleukin-1 receptor antagonist (IL-1RA) delivery to cartilage via electrostatic interactions, now published in Osteoarthritis and Cartilage! Osteoarthritis and Cartilage Journals Check it out! sciencedirect.com/science/articl…

New content online: Targeting osteoarthritis where it hurts: the osteochondral junction bit.ly/42I4dhg

Excited to share my first first-author paper! A big thank you to my wonderful co-authors. Check it out 50 days free:

Congratulations to Aiyana Fortin for her paper in Acta Biomaterialia describing extended joint residence time and chondrocyte internalization of C’Dot nanoparticles for #osteoarthritis therapy. #NSFfunded Wiesner Group Cornell BME  Materials Science and Engineering at Cornell