In this Opinion piece with Pavle Boskovic and Wenqing Gao we are comparing immune system in the brain to a road construction crew and proposing that cellular immunotherapies may be the solution for neurodegenerative (and maybe psychiatric?) disorders || Will cellular

Mass cytometry identifies senescent, TREM2-expressing #microglia in #Alzheimer’s disease model mouse brain that exhibit a distinct signature from TREM2-dependent disease-associated microglia (DAM) nature.com/articles/s4159…

I poured my soul into it… || The anatomy of brainwashing | Science science.org/doi/10.1126/sc…

Celebrating our amazing Wenqing Gao and her recently accepted beautiful paper 🎉🍾👏👏👏

🧵 Excited to share my first preprint from my PhD Kipnis Lab and The Colonna Lab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴 biorxiv.org/content/10.110…

Excited to share a new work from Kipnis Lab by amazing Wenqing Gao (twitter-less) on developing engineered T cell therapy for CNS injury || nature.com/articles/s4158…

#RethinkNeuroimmunology love the branded coffee!! IdoAmitLab Jonathan Kipnis 💔🎗️ Kiara Freitag

Our new review in ⁦Neuron⁩ with ⁦Li-Feng Jiang-Xie⁩ and ⁦Antoine⁩ on why you need to keep your brain clean so it ages slowly and well 😉 || Waste clearance shapes aging brain health sciencedirect.com/science/articl…

Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. Jonathan Kipnis 💔🎗️ nature.com/articles/s4158…

Our paper on guardian peptides that protect the brain from immune attacks (by Mitchell (Min Woo) Kim) is now available in its final format and with an open access! nature.com/articles/s4158…

Excited to have this work finally out… it addresses many controversies in the field and the take home message - if you are imaging your mouse keeping it in a particular head position, make sure to emphasize that because your data will be different from mouse images with another

Online now: Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease dlvr.it/THV094

On this President’s day we are celebrating (with some delay due to travels) a Lunar New Year with a group of scientists from more than 20 countries. That’s the face of American science. That what really makes America great. And that should never change!

🚨Paper alert 🚨 Our latest research is out in nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ Weizmann Institute Systems_Immunology_WIS 🔗 nature.com/articles/s4158… 🧵👇

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits || Meningeal

Fonta, Page, Merkler et al. show that #oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS #autoimmunity. IL-33 ablation reduces persistence and TCF-1low effector T cell generation, mitigating disease. hubs.la/Q03hcWPk0 #Neuroinflammation

Redefining CNS immune privilege bit.ly/432fwRC

Excited to share the review by ⁦Mitchell (Min Woo) Kim⁩ on how brain washing is linked to Neuroimmunology || Glymphatics and meningeal lymphatics unlock the brain-immune code: Immunity cell.com/immunity/fullt…

Nature research paper: Probing condensate microenvironments with a micropeptide killswitch go.nature.com/4jDiB0H

✨ My new cover for Immunity : Neuroimmunology in a Nutshell 🧠🌰 The image I created for Jonathan Kipnis 💔🎗️ and Min Woo Kim from WashU in St. Louis for St. Louis depicts a brain encased within an opening walnut shell. The concept represents the "cracking of the barriers" that once limited our