So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? 🚨Introducing STRAIGHT-IN Dual! 🧵 (1/n) Link: biorxiv.org/content/10.110…

Join us on Wednesday for another great pair of FragileNucleosome seminars!

Happy to share two post-doc papers co-authored with the amazing Ana Monteagudo-Sánchez and Teresa Urli. We had amazing collaborators for both projects, even our supervisor Maxim Greenberg joined in on the experimenting! 1: pubmed.ncbi.nlm.nih.gov/39180406/ 2: rdcu.be/dXXqh

The research project that got the lab off the ground has been published in NatureStructMolBiol 🥹. I couldn't do a better job of summarizing than co-lead author Julien Richard Albert , so he'll take it from here! (and makes unexpected connections with our other recent study)

Finally, out in Science Magazine today, our work on de novo protein design. Together with Motoyuki Hattori (服部素之) , Sergey Ovchinnikov & @hendrik_dietz we showed how we can drastically improve AF2 based hallucination, surpassing, or reaching SOTA diffusion models doi.org/10.1126/scienc…

🚨New Review🚨 We've recently seen huge advances in our understanding of de novo DNA methyltransferase function. Willow Rolls and Marcus D Wilson and I have written a mini-review on what human disease mutations told us: doi.org/10.1042/BST202… #Epigenetics #Epigenomics 🧵 1/2

Excited to see this study go online! Thank you Neil Brockdorff,Tatyana & friends Brockdorff Lab Here we set out to dissect the contributions of individual domains of DNMT3B in imparting it the specificity for its target loci. Read on for summary [1/12] biorxiv.org/content/10.110…

Are any of my condensate / phase separation / RNA biology colleagues aware of any upcoming special editions at journals focused on biomolecular condensates?

How are promoter interactions coordinated during cell differentiation? In our first paper, we investigate the temporal relationship between genome folding, transcription and histone modifications during ESC differentiation. (1)

also if your departments are looking to hire a delightful junior prof whose research vision is to understand the functional consequences of alternative splicing...... I might know a gal 😎

Exploring gene duplications! Our study reveals how duplicated genes diverge in function using structural and expression analysis across 36 species. Check out our paper: biorxiv.org/content/10.110… Thanks to Alex WV, Natasha Glover, Paul Thomas, Christophe Dessimoz #Genomics #Evolution

In the midst of stressful times, let's come together to listen to 3 amazing talks by 3 brilliant ECR scientists. Alex, Wilson and Xiukun will present their research tomorrow at 9am PDT/ 5pm GMT/ 6pm CET! Register: us06web.zoom.us/webinar/regist…

Increases to NSERC Discovery Grants: Budget 2024 funds will be ramped up over the next 5 years, with $20.4 million this 1st year & increasing to $227 million per year in year 5 & ongoing. These increases will enable researchers to better support students & postdoctoral fellows.

A big new batch of our FragileNucleosome seminar videos have gone public in the past couple weeks! Here's a thread 1/9

NCI is taking applications for antibody pdtn, with deposition in the DSHB! This is a fantastic resource, and every protein added gives us an affordable/reproducible reagent. It'd be amazing if many chromatin folks submitted their proteins (hint hint): proteomics.cancer.gov/antibody-porta…

Metabolism and epigenetics sync up! 🌀 Histone acetylation not only activates genes but also acts as an acetate reservoir. #Metabolism #Epigenetics #HistoneAcetylation. Thank you Kirmizis Lab! More details Trends in Biochemical Sciences authors.elsevier.com/a/1k3PJ3S6GfQa…

Check out our new review! The Two Faces of HDAC3: Neuroinflammation in Disease and Neuroprotection in Recovery tandfonline.com/doi/full/10.10…

A tweetorial for our work: we revealed an actionable therapeutic vulnerability of ecDNA by targeting hyperreliance on the replication stress (RS) regulation machinery in ecDNA-bearing tumour cells, which arises from pervasive transcription on ecDNA. 1/14 nature.com/articles/s4158…

Science friends heading to the Other Place 🌌—let’s not lose each other in the void. Over the next few weeks, I'll try to put together some science "starter packs" of who to follow. Fill out this form to be included. bit.ly/sci-starterpack Share widely ❤️