Cell type-specific delivery by modular envelope design nature.com/articles/s4146…

Incredible work on cell type specific delivery from my labmate Daniel Strebinger ! Check out his thread below for details!

Excited to announce the opening of the Strecker lab at MGH Molecular Biology/CCIB and HMS Genetics. I am tremendously grateful to all of my labmates who have helped me over the years, my past mentors @durocher1 and Feng Zhang, and my new colleagues Dept. of Molecular Biology, MGH for the opportunity!

wschneider and I are happy to announce the 6th series of the Systems Virology Journal Club! ✨ Join us to learn about the exciting research at the intersection of virology and systems biology. Registration (free): forms.gle/edTyLwR8jWkhrR…… Webpage: shiraweingartengabbay.com/systems-virolo…

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

The Raguram Lab is recruiting at all levels! If you’re excited about studying intercellular biomolecule transport and developing new protein delivery technologies, apply to join our team Whitehead Institute. Learn more here: raguramlab.org

What if you could recombine any two DNA sequences in a programmable manner? We discovered an RNA-guided recombinase that can do just that! So happy to have co-led this project with Nicholas Perry

You call it the systems biology department, but to me it’ll always be

1/8 How can we enrich cells with a defined transcriptional state, but without killing them? Please read on! biorxiv.org/content/10.110…

So excited to announce that the Kappel Lab will open at UCLA UCLA Chem & Biochem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here: sites.google.com/view/kappellab/

Thrilled to share our recent work out today in nature on an mRNA therapeutic to treat pre-eclampsia! This work has been a true passion project from my time Penn Bioengineering in Mike Mitchell, and I’m excited to continue important research in women’s health! nature.com/articles/s4158…

1/ Thrilled to share an advancement in gene therapy from my PhD in Nature Communications! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to Feng Zhang & Mirco J. Friedrich! bit.ly/redicas9

Congratulations to Rumya Mirco J. Friedrich Daniel Strebinger Blake Lash Cyrus Biotechnology and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and

Today, we are launching the first publicly available AI Scientist, via the FutureHouse Platform. Our AI Scientist agents can perform a wide variety of scientific tasks better than humans. By chaining them together, we've already started to discover new biology really fast. With

Evolution-guided protein design of IscB for persistent epigenome editing in vivo go.nature.com/44XVBph

Today, we’re announcing the first major discovery made by our AI Scientist with the lab in the loop: a promising new treatment for dry AMD, a major cause of blindness. Our agents generated the hypotheses, designed the experiments, analyzed the data, iterated, even made figures

At FutureHouse, we’ve noticed scientific agents are good at applying average intelligence across tasks. They always seem to make the obvious choices, which is good, but discovery sometimes requires more intuition and insight than average. We’ve made the first step today towards

Today we are releasing ether0, our first scientific reasoning model. We trained Mistral 24B with RL on several molecular design tasks in chemistry. Remarkably, we found that LLMs can learn some scientific tasks more much data-efficiently than specialized models trained from

Beautiful work by @GraceKC !! RTs, RNA, LNPs, structures, what a paper! (And how cute is that bird!!)

Woah, this is really cool! Functional phage from generative models! Can’t wait to see what other things can be made!