Beyond favoring cPRC1 condensate polycomb bodies, H3.3K27M mutations alter another nuclear compartment; promyelocytic leukemia (PML) bodies, with implications for impaired glioma differentiation in work by the group of Lee Wong: genomebiology.biomedcentral.com/articles/10.11…

Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes dlvr.it/T2MGmV

Excited to share our new preprint on the interaction between DNMT3A1 and H2AK119Ub. This work is the fruit of a collaboration between Lu Lab_Columbia, @KJArmache Lab and EpiCypher, Inc. and co led with @Xagbomson biorxiv.org/content/10.110…

Now online! TULIPs decorate the three-dimensional genome of PFA ependymoma dlvr.it/T9ND3b

Our paper where we characterize the immune TME of oncohistone gliomas is out Nature Communications. We applied transcriptomic, proteomic and spatial single-cell approaches, and multiple syngeneic mouse models nature.com/articles/s4146… 🧵1/

What are oncohistones and how do they play a role in cancer? This new article by Wajih Jawhar وجيه جوهر from the Canadian Epigenetics trainee committee gives you an introductory primer! #ThisIsEpigenetics thisisepigenetics.ca/about-epigenet…