Gene function is associated with distinct mRNA – protein levels. We show that mRNA, protein, and mRNA-protein levels are associated with sequence characteristics in human CD8+ T cells. In the lab of @WolkersMonika at Sanquin You can read more here: dx.plos.org/10.1371/journa…

Identification of patient-specific CD4⁺ and CD8⁺ T cell neoantigens through HLA-unbiased genetic screens go.nature.com/3Ida0mm

Follow the Schumacher lab! (Exciting stuff coming up)

Woohoo 🙌🙌🙌! If you’re into immunology and immunotherapy, then you must know Ton Schumacher! Follow the lab’s new twitter account! The Netherlands Cancer Institute

Follow our cancer immunology colleagues The Netherlands Cancer Institute

Excited to share STAPLER, a language model to predict TCR – pMHC reactivity that outperforms prior models. And for ML aficionados: Description of a new data leakage problem inherent to a common negative data generation strategy. biorxiv.org/content/10.110… 🧵👇

Preprint alert 🚨🚨 Large language models can predict TCR - pMHC reactivity!🧬🔬 Proud to have worked on this project with MariusMessemaker and all other amazing co-authors.

We’re excited to reveal that Team MATCHMAKERS has been selected by Cancer Grand Challenges to receive up to $25m over five years to take on one of cancer’s toughest challenges. Congratulations to Ton Schumacher Ton Schumacher Lab and all the #CancerGrandChallenges teams!

Researchers from the group of John Haanen and Ton Schumacher Lab have successfully developed a novel method that enables the identification of T cell receptors at an unprecedented scale ➡️ bit.ly/3Ql6ObG

Ton Schumacher is closing #CancerHostTI24 discussing neoantigens and neoadjuvant therapy. With his research group he created technologies to dissect T cell responses in cancer and contributed to the development of adoptive T cell therapies and neoadjuvant cancer immunotherapy.

Congratulations David Baker (University of Washington, member of #CancerGrandChallenges team MATCHMAKERS), who's won the 2024 Nobel Prize in Chemistry for his pioneering work building new kinds of proteins! 👏 More about MATCHMAKERS, funded by Cancer Research UK National Cancer Institute The Mark Foundation for Cancer Research 👉 cancergrandchallenges.org/matchmakers

#ESMOImmuno24: According to the 2024 ESMO Immuno-Oncology Awardee, Ton Schumacher Lab, tackling the T-cell receptor challenge w/ vast datasets and cutting-edge high-throughput methods may pave the way for advances in #immunotherapy. #ESMODailyReporter 📌ow.ly/rZUO50Up0BE

A functionally validated TCR-pMHC database for TCR specificity model development biorxiv.org/content/10.110… #biorxiv_immuno

Incredibly excited and grateful for the opportunity to present at Antwerp TCR in 3 weeks. There’s no place more relevant to showcase what we have been up to. If you want to have a sneak preview; check out the thread of MariusMessemaker & our pre-print biorxiv.org/content/10.110…

Alongside TCRvdb, we introduced TCRbridge - an AlphaFold3-based model for predicting TCR-pMHC specificity (built upon AlphaBridge). The code is now live on GitHub 👉github.com/schumacherlab/…