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📢 Finally out now: Our paper describing DigitISA, a platform for direct digital sensing of protein biomarkers in solution 🧪 (incl. antibodies, amyloid aggregates & condensates). KnowlesLab Cambridge Cambridge Chemistry Take a look: 👇nature.com/articles/s4146…

Great to see our paper on DigitISA - a #microfluidic platform for direct detection of protein-based biomarkers - published in Nature Communications nature.com/articles/s4146… DigitISA allows detecting markers that have remained challenging with surface-based immunoassays, such as amyloid

Our paper on the digital sensing of protein:aptamer interactions is finally published! One platform shows the ability to sense everything from single proteins up to biomolecular condensates and exosomes, while elucidating many biophysical parameters. Congrats to all authors!

Check out the new DigitISA assay for sensing biomolecular complexes in solution! Well done Georg Krainer Kadi-Liis Saar Tim Welsh Magda Czekalska Raphaël P. B. Jacquat and colleagues from Owens, Alberti and Klenerman groups! nature.com/articles/s4146…

📃 Our latest work is out! Sizing of single proteins using nanofluidics. 🧪 Great collaboration with Raphaël P. B. Jacquat and many others KnowlesLab Cambridge Cambridge Chemistry & in collaboration with #baumberglab,KeyserLab & Laser Analytics Group (Kaminski Lab) pubs.acs.org/doi/10.1021/ac…

Appointed tenure at ETH Zurich. I'm grateful to my inspiring mentors, current and former group members, colleagues and collaborators, for all the support, dedication and contributions along the way. Looking forward to the new exciting projects in front of us!

🔓 #OpenAccess + Most Read in the past 30 days: "Single-Molecule Sizing through Nanocavity Confinement" by Raphaël P. B. Jacquat, Georg Krainer, Peter, Babar, Vanderpoorten, Xu, Welsh, Kaminski, Keyser, Baumberg, & Knowles go.acs.org/48Z

New PostDoc position! Join the vibrant LIAC team (LIAC at EPFL) for a project on “ML for Direct Air Capture Materials”. Develop models to accelerate the discovery of new CO2 adsorbents together with excellent experimental collaborators (LFIM - Wendy L. Queen)! RT appreciated. #ML4Sus

Review: Amyloid formation as a protein phase transition By Thomas Michaels, Daoyuan Qian, Andela Saric, Michele Vendruscolo, Sara Linse & KnowlesLab Cambridge rdcu.be/dfzMr

New preprint alert.🔬💧🔬 In collaboration with Shin Lab, we show that diffusiophoresis is a general non-equilibrium thermodynamic force that governs biomolecular condensates' localization and active transport independent of motor proteins. tinyurl.com/3mua8ma8

Very excited to finally see this out Nature Chemistry! The interface of hnRNPA1 LCD condensates promotes the transition to amyloids. Thanks to everyone involved for their important contributions! Paolo Arosio D-CHAB ETH Zurich nature.com/articles/s4155…

Preprint alert !! Introducing 🙌XpertAI🙌 - a new framework that combines explainable AI (XAI) methods with large language models (LLMs) to generate natural language explanations of structure-property relationships from raw data. Link to the preprint: arxiv.org/abs/2311.04047

We had the chance to present our work at the United Nations's Science, Techonology, and Innovation forum. Thank you to everyone who has supported us along the way 😊, and a special thanks to Engineering for Change for enabling us to present alongside the other selected innovators.

Excited by the possibility of proteins being able to generate distinct pH microenvironments without needing mebrane enclosure, active transporters or energy input! KnowlesLab Cambridge

Looking foward to attending the GRC conference on IDPs in the Swiss Alps!🏔️ I'll be presenting our latest work on modulating enzymatic activity within condensates across length scales. Can't wait to connect with fellow IDP enthusiasts! IDP GRC nature.com/articles/s4146…

Universal cold RNA phase transitions | PNAS pnas.org/doi/10.1073/pn…

Very excited to share our work in Nature Communications! We show that a-synuclein oligomers and fibrils form by secondary nucleation on existing fibril surfaces nature.com/articles/s4146…

Ever wondered what's in the air you breathe? Explore our new urban air quality maps! Featuring data from Kigali, Lisbon & Stockholm, collected via mobile PM2.5 sensors & citizen science. Discover pollution patterns to inform evidence-based solutions 👉 maps.open-seneca.org