Recently, protein aggregation has burst into biology, proving to be the key mechanism of a number of vital processes. To assess the scale of this phenomenon, we performed the first bioinformatics analysis of 76 proteomes doi.org/10.1093/bib/bb… CRBMUniversité de Montpellier
The #ML4NGPmeeting sessions on #ML and #ProteinRepeats were phenomenal! A special thank you to Andrey Kajava CRBM and Miguel Andrade Mainz University and all attendees for insighful discussions
IDPfunREFRACT #COSTactions
Our 2nd workshop has just started in Montpellier 🇫🇷 CRBM hosted by Andrey Kajava KAJAVA TEAM!
We aim to promote an open discussion on methodologies for characterization of tandem repeat #proteins!
ml4ngp.eu/workshop-montp…
#ML4NGPteam #ML4NGPresearch REFRACT
Despite the growing understanding of the importance of co-aggregation induced by amyloidogenesis, methods for prediction of co-aggregation are absent. We developed AmyloComp, the first software designed specifically for this purpose. doi.org/10.1016/j.jmb.…
Introducing Cross-Beta DB : a database of in vivo cross-beta amyloid structures. Harnessing this this meticulously curated data, we've developed a cutting-edge AI predictor that surpasses current methods. doi: doi.org/10.1101/2024.0…
Protein tandem repeats: What if the reading frame is shifted?
We explored an 'alternative world' of proteins by analyzing amino acid sequences resulting from frame shifts in their genes, focusing on tandem repeats as frameshift hotspots.
doi: doi.org/10.1101/2024.0…
Our AI-driven "Cross-Beta Predictor" for protein amyloid prediction is now published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association : doi.org/10.1002/alz.14….
Can it be used for amyloidosis diagnosis?
#AI #Healthcare #AlzheimersResearch