BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Yay, the all-new MRC Laboratory of Molecular Biology 2023 #cryoEM lectures are now online on YouTube! Happy learning. 🥳 youtube.com/playlist?list=…

2023, in 7 minutes youtu.be/sJs_64OUpEs?si… via YouTube

Biology and Neuroscience - 2023's Biggest Breakthroughs youtu.be/qt6BO-DV0pY?si… via YouTube Watch it till the end, the last one is fascinating..

From AI to the Y chromosome (and everything in between) Our editors pick their favorite research articles from 2023 go.nature.com/3uMSHnm rdcu.be/duKJ3

Over 13 years ago, Ginkgo Bioworks Bioworks released this video Jason Kelly $DNA

I wrote down my rules on how to Science. I hope you find it useful!

The 2024 #STATUSList is officially here! See STAT's third annual list of leaders shaping the future of health and the life sciences: trib.al/VQxdxdO

GTC March 2024 Keynote with NVIDIA CEO Jensen Huang youtube.com/live/Y2F8yisiS… via YouTube

Cast your vote here for Round Eleven of #SynchrotronMugMadness 3: The Return of the Mug below.

Completely full house at BPDMC last night – thanks to Sergey Ovchinnikov for a brilliant tour and discussion of AlphaFold3 architecture, usage, and idiosyncrasies. My notes below, ft. AF3 tips, tricks, and warnings shared by Sergey. 👇🏽 1/12

This is an interesting idea: turning a cancer's drug resistance against it These are growth curves of tumours in mice, treated with a drug (a tyrosine kinase inhibitor). The tumours initially shrink but they all - slowly but surely - become resistant: This study aimed to convert

The authors in this manuscript deserve a shout it! I was once asked to purify this protein, FMRP (in HEK back then) in 2019? Failed hard. They found (2020) a way: non cleaved MBP-fusion and a P>S mutation in two steps in Ecoli. And it works so well just look at what I got!

I participated in the Adaptyv Bio competition to design an EGFR binding protein design.adaptyvbio.com. I'll outline the process that led to this wide range of rankings in my submissions. 1/

I'm going to keep saying this until someone proves me otherwise: AlphaFold(2, 3, 10000, whatever) or any structure prediction tool will not generalize to protein conformations if its training is optimized to "ground truth" structures in the PDB! Crystallized or cryo-EM structures

When breast cancer cells lack glutamine, they use alpha KG as their fuel source instead. CSHL’s Michael Lukey discovered how to deprive the cancer cells of both sources, which ultimately killed the cancer cells and shrank tumors in mice. cshl.edu/how-breast-can…

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…

We're releasing a preview of OpenAI o1—a new series of AI models designed to spend more time thinking before they respond. These models can reason through complex tasks and solve harder problems than previous models in science, coding, and math. openai.com/index/introduc…

The wait is over. OpenAI just dropped o1, also known as Project Strawberry/Q* This is new level of AI that can "think" and "reason" before responding to you. 10 wild demos: 1. Coding Video Game from a prompt

Rosetta Workshop 2024 meilerlab.org/rosetta-worksh…