Reduction of prime editing errors by engineered Cas9 variants with relaxed nick positioning. #NBThighlight nature.com/articles/s4158…

Small nuclear RNAs increase the efficiency of programmable RNA editing on endogenous human transcripts #NBThighlight nature.com/articles/s4158…

The recently discovered giant virus PelV-1 has a tail of unprecedented length. Learn more: scim.ag/4ffxrtD News from Science

Destabilized variants of MS2 and PP7 coat proteins offer improved live-cell imaging of tagged RNAs in mammalian cells. nature.com/articles/s4159…

Now online! Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains dlvr.it/TNGGY5

Yifan Cheng to Receive 2026 Anatrace Membrane Protein Award buff.ly/ooI1UDy

📢Congrats to Qionghai Dai on their review "Intravital mesoscale optical imaging: challenges, techniques, and future perspectives" published in Biophysics Reports (Online First). 🔗doi.org/10.52601/bpr.2… #IntravitalMicroscope #MesoscaleOpticalImaging #SpaceBandwidthProduct

Online now! Flexibility or uncertainty? A critical assessment of AlphaFold 2 pLDDT dlvr.it/TNHb9k

Online now! Structural insights into IL-31 signaling inhibition by a neutralizing antibody dlvr.it/TNJgdv

2024 #NobelPrize laureate in chemistry David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins. In recent years, one incredible protein creation after the other has emerged from Baker’s laboratory. They range from new nanomaterials

Discovery and protein language model-guided design of hyperactive transposases go.nature.com/4gXLGEw

Online now! Structural basis for DCAF2 as a novel E3 ligase for PROTAC-mediated targeted protein degradation dlvr.it/TNYB4Q

A principled framework is provided for identifying the number of structurally meaningful classes in cryo-EM data sets Structural Biology IUCr #CryoEM #3DClassification #StructuralHeterogeneity doi.org/10.1107/S20597…

New Article! Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states bit.ly/4nI4OJb

Unintended proteins can easily sneak into experiments, but cryo-EM shows surprising power to uncover these `off-target' proteins in great detail Sabancı Üniversitesi @bristoluni Structural Biology IUCr #CryoEM #ArnA #AcrB doi.org/10.1107/S20597…

Issue 9 of Protein&Cell here! academic.oup.com/proteincell/is…

📢 Congratulations to Peng Fei on their review "Technological innovations and high-throughput applications of light-sheet microscopy" published in Biophysics Reports (Online First). 🔗 doi.org/10.52601/bpr.2… #LSFM #Highthroughput #SampleCompatibility

📢 Congratulations to Qiang Guo on their study "Optimized tissue sample preparation for cryo-electron tomography using serial lift-out" published in Biophysics Reports (Online First). 🔗 doi.org/10.52601/bpr.2… #CryoET #Tomography #CryoFIB #InsituStructuralBiology

📢 Congratulations to Kai Huang on their review "Cyclic stretch and oxidative stress induced miRNAs in vascular remodeling" published in Biophysics Reports (Online First). 🔗 doi.org/10.52601/bpr.2… #smiRNAs #Cyclicstretch #Mechanotransduction #Oxidativestress #ROS

📢 Congratulations to Yifei Yao on their study "Multi-scale analysis of mechanical stress in muscle under static and dynamic loading" published in Biophysics Reports (Online First). 🔗doi.org/10.52601/bpr.2… #CyclicforCestimulation #FiniteElementAnalysis