Mikołaj Słabicki 🇺🇦 (@biomiko) 's Twitter Profile
Mikołaj Słabicki 🇺🇦

@biomiko

Group Leader, Scientist characterizing the molecular mechanism of drugs inducing protein degradation at @broadinstitute, @DanaFarber. Tweets are my own.

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calendar_today21-01-2016 17:31:23

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Mikołaj Słabicki 🇺🇦 (@biomiko) 's Twitter Profile Photo

Interested in drug induced proximity, cutting-edge drug research? Consider joining or collaborating with the leading scientist in TPD at #NowakLab. Boston misses you, but your next chapter at #UniBonn looks promising!

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Join us for our last DegradoZoom of 2023, featuring University of Bonn's Radek Nowak Radek Nowak on 'Structure-based Design of Covalent Cereblon Binders' and Christian Steinebach Christian Steinebach on 'Targeting the Ubiquitin-Proteasome-System with PROTACs.' Thursday, Dec 14th, 11am EST

Join us for our last DegradoZoom of 2023, featuring University of Bonn's Radek Nowak <a href="/RPNowak/">Radek Nowak</a> on 'Structure-based Design of Covalent Cereblon Binders' and Christian Steinebach <a href="/c_steinebach/">Christian Steinebach</a> on 'Targeting the Ubiquitin-Proteasome-System with PROTACs.' Thursday, Dec 14th, 11am EST
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Excited for the seminar with Bill Kaelin & Matt Boudreau on positive selection screens for degraders! Can't wait to dive into this cutting-edge topic. Join us today at 11 AM EDT.

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I am eagerly anticipating tomorrow's seminar, which will focus on Molecular Glues, presented by Amanda Ng and William Donald (William A Donald). Please join us at 11 am EDT.

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Can we conjugate ubiquitin in a non-canonical fashion? Join Breanna Zerfas and me for two compelling seminars at 11 am EDT, 8 am PT, 4 pm BST, 5 pm CEST: Jonathan Ostrem: “Direct Small Molecule Ubiquitination” Darci Trader: “Bypassing an E3 Ligase for TPD"

Can we conjugate ubiquitin in a non-canonical fashion? Join <a href="/BLZerf6/">Breanna Zerfas</a> and me for two compelling seminars at 11 am EDT, 8 am PT, 4 pm BST, 5 pm CEST: <a href="/JonathanOstrem/">Jonathan Ostrem</a>: “Direct Small Molecule Ubiquitination” 
Darci Trader: “Bypassing an E3 Ligase for TPD"
Mikołaj Słabicki 🇺🇦 (@biomiko) 's Twitter Profile Photo

Join our next TPD Webinar, 2nd May, 11AM EDT/ 8AM PT/ 4PM BST / 5PM CEST Stuart Conway, Patrick Brennan - 'Bringing Bump-and-Hole to Molecular Glues: The Development of Orthogonal IMiD-Degron Pairs' Diane Haakonsen - 'Stress Response Silencing in Neurodegenerative Disease'

Join our next TPD Webinar, 2nd May, 11AM EDT/ 8AM PT/ 4PM BST / 5PM CEST
<a href="/conway_group/">Stuart Conway</a>, <a href="/PatrickJosephB/">Patrick Brennan</a>  - 'Bringing Bump-and-Hole to Molecular Glues: The Development of Orthogonal IMiD-Degron Pairs'
<a href="/DianeHaakonsen/">Diane Haakonsen</a> - 'Stress Response Silencing in Neurodegenerative Disease'
Mikołaj Słabicki 🇺🇦 (@biomiko) 's Twitter Profile Photo

Join us tomorrow for our next TPD session at 11 AM EST: Sandi Radko-Juettner & Hong Yue “Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF”and Francis Barany “CURE-PROs – Reversible, Self-Assembling Drugs for Targeted Protein Degradation”.

Join us tomorrow for our next TPD session at 11 AM EST: Sandi Radko-Juettner &amp; <a href="/HongYue88665668/">Hong Yue</a>
“Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF”and
Francis Barany “CURE-PROs – Reversible, Self-Assembling Drugs for Targeted Protein Degradation”.
Mikołaj Słabicki 🇺🇦 (@biomiko) 's Twitter Profile Photo

Join us today for a discussion on the newest methods to identify ubiquitinated proteins, discussed by: Hubert Huang, Rosa Barrio, James D. Sutherland, Sagar Bhogaraju, Christian Behrends.

Mikołaj Słabicki 🇺🇦 (@biomiko) 's Twitter Profile Photo

Join us tomorrow for the next #DegradoZoom! We will feature "FBXO22 Molecular Glue" by Elisia Villemure and "Targeting Oncogenic RAS" by Kyle Seamon.

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Endogenous polymerization of BTB domains: Our initial hypothesis was that this would lead to protein degradation, but instead, polymerization led to enhanced chromatin binding at homotypic clusters, causing transcriptional repression. Great story spearheaded by amazing Park Team!