🐓 Key gene that blocks the spillover of #AvianFlu to humans discovered. Rute Maria Pinto, @WilsonLabCVR & colleagues have identified that the BTN3A3 gene is vital to protecting humans against avian flu. 📄 Paper: nature.com/articles/s4158… 🗞️ News article: gla.ac.uk/news/headline_…

🎉Exciting Update of scGPT 🎉: After receiving significant attention from the community since our April release, we're thrilled to announce the first major update for scGPT - a foundation model for single-cell multi-omic data. This update integrates community feedback and

Congratulations Dr Oumie Kuyateh, PhD ! What viruses do lab flies commonly have, and what might this do to gene expression? biorxiv.org/content/10.110…

Are you or do you know an evolutionary biologist working non-in-academia? See below, and please retweet! Link to survey: liverpool.onlinesurveys.ac.uk/non-academic-c….

Researchers Billy Palmer and @PN0rmski from CU Department of Biomedical Informatics (DBMI) report their investigation of a potential new immune checkpoint target (KIR3DL3/HHLA2) - work which could inform new approaches cancer treatment. news.cuanschutz.edu/news-stories/c…

Absolutely delighted to share our paper detailing an HLA association with asymptomatic SARS-CoV-2 infection, out today in nature UC San Francisco with GRAS Lab Danillo Augusto Joe Sabatino Martin Maiers Steve Spellman Lawton Murdolo Dimitra Chatzileontiadou nature.com/articles/s4158…

I’m excited to share some work I co-lead with Rodrigo I Castro and spanned the labs of Pardis Sabeti, Steve Reilly, and Ryan Tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n

A mass screening of immune activating receptors on natural killer cells shows how different peptide variants can affect innate immunity. Malcolm Sim NIAID News Check out the study: scim.ag/43l

What gets erased when you integrate #singlecell data across samples/studies, and can you get it back? When samples are from e.g. healthy & disease, should you simply massage cells together? FINALLY, I feel we can answer this question: doi.org/10.1101/2023.0…

🔥🚨Targetals funded TDP-43 RNA aptamer preprint🚨🔥 Using deeply phenotyped #ALS post-mortem tissue cohorts we show nuclear TDP-43 pathology is an early event, co-incident with STMN-2 cryptic splicing, preceding cytoplasmic aggreg. & symptom onset 🧵1/4 biorxiv.org/content/10.110…

Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus Science Magazine Badr Singer science.org/doi/epdf/10.11…

50-color phenotyping of the human immune system with in-depth assessment of T cells and dendritic cells biorxiv.org/cgi/content/sh… #biorxiv_immuno

Don't like p-values? We're presenting a completely new interpretation in the context of clinical trials. With Andrew Gelman, Sander Greenland, guido imbens Simon Schwab and Steve Goodman. Sander Greenland Steven Goodman NEJM Evidence evidence.nejm.org/stoken/default…