We are very excited to share our most recent publication showing that functional hyperemia drives CSF influx and clearance in mice. nature.com/articles/s4159… Stephanie Holstein-Rønsbo Maiken Nedergaard Michael Giannetto drfelix Verena Untiet Lauren Hablitz 1/9

Microbes pack #gasvesicle into tight bundles to save their cytosolic space, and yet the molecular mechanism underlying this process remains unknown. Now we may know why. Grateful to our collaborators Chilkoti Lab and Lingchong You. More detail -> (1/n) biorxiv.org/content/10.110…

#gasvesicle requires a coordinated effort of 7-20+ proteins to assemble. As a first step to unravel this intriguing process, we constructed a systematic protein interaction map and hypothesized proteins in each assembly stage. Big cheers Manuel Iburg & co. biorxiv.org/content/10.110…

Excited to share our study on the blood interactions of GVs! Special thanks to Jeong Hoon Ko (JK) for developing the surface functionalization chemistry and Ben Stordy The Chan Lab for their work on the protein corona!

🚨🚨🚨New paper🚨🚨🚨 @Matt___Nguyen et al. found that NPs exit solid tumours through the lymphatics in a size dependent mechanism, and proposed a new mechanism of NP delivery to tumours called the Active Transport and Retention (ATR) principle 🥵🌶️ tinyurl.com/4p7ymkjn

New technologies to study the hallmarks of cancer! Congrats @mijinee_hi and Magdalini Panagiotakopoulos and colleagues at Memorial Sloan Kettering Cancer Center on putting together this terrific review of micro/nanotechnology approaches to investigate tumor ecosystems, in Nature Cancer. nature.com/articles/s4156…

Can a living material made of bacteria sense when it's too cold and make a chromophore to heat itself up with sunlight? 🌞 Yes, using thermal bioswitch circuits! Congrats Lealia Xiong, Michael Garrett and collaborator Julia Kornfield on this paper. onlinelibrary.wiley.com/doi/10.1002/ad…

Delighted to share the latest paper from The Robb Group in collaboration with Mikhail Shapiro (same on bsky) 🇺🇦’s group online now in PNASNews. Mechanophore activation using #biocompatible focused ultrasound! Huge congrats to Molly McFadden and Yuxing Yao and coworkers! doi.org/10.1073/pnas.2…

Excited to start my new journey as an Assistant Professor Duke Engineering Most sincere gratitude goes to my supervisors and mentors: @JulianRimoli , Rafael de la Llave, Michael Ortiz, Mikhail Shapiro (same on bsky) 🇺🇦, Ravi... and thanks to many incredible colleagues at Georgia Tech and Caltech

Magneto-gas vesicles, protein nanostructures with enhanced ultrasound signal and sensitivity, enable the non-invasive, long-term and quantitative monitoring of the mechanics of three-dimensional tissues and animals Yonsei University Mikhail Shapiro (same on bsky) 🇺🇦 IBS_media(기초과학연구원) go.nature.com/3ZVwcZ7

Can we image intracellular calcium with ultrasound? Yes, w/ultrasonic reporters of calcium - URoCs! Congrats to Zhiyang Jin and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on #gasvesicles. biorxiv.org/content/10.110…

Forest Neurotech is hiring! Three roles on the engineering team (Palo Alto, CA) - Principal Mechanical Engineer - Principal Electronics Systems Engineer - Principal Engineering Program Manager @ all my Neurotech friends -- please share 😊 forestneurotech.org/jobs

A paper from my PhD is officially out today at Nature Neuroscience where Sumner L Norman and I demonstrate a closed-loop ultrasound-based brain-machine interface (BMI)!! Link to paper - nature.com/articles/s4159… A #tweetprint. 🧵1/12

Where do #gasvesicles live in a mammalian cell? The cytoplasm, as we can see w/bioorthogonal labeling w/FlAsH! Congrats to Erik Schrunk, co-sr auth Di Wu & co on a fractional labeling method that may also be useful for other protein nanostructures. biorxiv.org/content/10.110…

Can’t wait to take the next step with motif neurotech! This funding will allow us to launch the first clinical trial with magnetoelectric-powered implants - a new architecture for neuromodulation. Credit to team at Motif and the supportive environment at Rice and the Launchpad!

Can you evolve an acoustic protein? Yes, but first you have to invent a system for high throughput acoustic screening! Congrats to Rob Hurt, Zhiyang Jin and colleagues on this advance in biomolecular ultrasound. #gasvesicles biorxiv.org/content/10.110…

#gasvesicles are tiny gas-filled organelles that serve as flotation devices for microbes, and microbes pack them in a beautiful honeycomb pattern to maximize space-saving. What is the protein that regulates this process, and what is the role of #condensate? See our paper

Congrats to Dr. Zhiyang Jin on a phenomenal PhD thesis defense on acoustic biosensors! 🎉 Zhiyang's work broke fundamentally new ground in connecting ultrasound to dynamic cellular signals such as proteases and calcium.