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Here is the first paper, which shows that variants in only 13 influenza susceptibility candidate genes that govern TLR3- and IRF7-dependent production of type I IFNs account for at least 3.5% of critical cases of #COVID19 science.sciencemag.org/content/early/… Science Magazine

Here is the other paper, which shows that neutralizing auto-Abs to type I IFNs account for at least 10% of critical cases of #COVID19, even in a greater proportion in men: an auto-immune phenocopy of the corresponding inborn errors science.sciencemag.org/content/early/… Science Magazine

Big jumps in science of Type 1 Interferon response to #COVID19 today Science Magazine: auto-antibodies, genomic variants, together account for ~14% of critical/life-threatening covid patients science.sciencemag.org/content/early/… science.sciencemag.org/content/early/… sciencemag.org/news/2020/09/h… Meredith Wadman

BREAKING NEWS: The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”

Rogue Antibodies and Gene Mutations Explain Some Cases of Severe COVID-19 – NIH Director's Blog directorsblog.nih.gov/2020/10/06/rog…

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

“My wish is that this will provide a positive message to the young girls who would like to follow the path of science, and to show them that women in science can also have an impact through the research that they are performing.” - 2020 Chemistry Laureate Emmanuelle Charpentier.

Congrats to Dr. Charles Rice of Rockefeller University on winning the #NobelPrize in Medicine! Dr. Rice is a co-chair of NY's independent Clinical Advisory Task Force that will advise the state on future COVID vaccines. We're lucky to have his advice and expertise.

The test positivity rate in the “Red Zone” focus areas is 4.95%. The statewide positivity rate excluding Red Zones is 0.96%. We are taking strong action to respond to these outbreaks and to stop the spread. Mask Up.

Unprecedented. Editors nature on Trump (disregard for science, truth, facts w/ devastating consequences) and endorsement for Biden. Adds to Science Magazine NEJM @Lancet nature.com/articles/d4158… x.com/EricTopol/stat…

Took a little time from the campaign trail to view some photos throughout my life—the people and places that made me who I am today.

It's our differences in the interferon pathway, our 1st line innate immunity defense, that help explain why we respond so differently to #SARSCoV2. Lucid context for 2 recent papers nature.com/articles/d4158… by Eric Meffre Prof. Akiko Iwasaki Nature News & Views Yale Department of Immunobiology Yale School of Medicine HHMI

Interferon deficiency can lead to severe COVID nature.com/articles/d4158…

Today is a good day. It’s easier to be a parent this morning. Character MATTERS. Being a good person MATTERS. This is a big deal. It’s easy to do it the cheap way and get away with stuff — but it comes back around. Today is a good day. #PresidentBiden #VotersDecided

Tonight, the whole world is watching America. I believe at our best America is a beacon for the globe. And we lead not by the example of our power, but by the power of our example.

My lab is recruiting! If you are a motivated researcher looking for a PhD or PostDoc position, interested in working on ADA2 deficiency and related PIDs in a ⁦European Research Council (ERC)⁩ / @fwo funded project, at ⁦KU Leuven⁩, find more info here: gbiomed.kuleuven.be/english/resear…

Excited to share our new manuscript showing volumetric Ca #imaging of 1 million neurons across the mouse cortex at cellular resolution using Light Beads #Microscopy (LBM). bit.ly/2Nw82mY Congratulations to the entire team! #neurocience #optics #neurotechnology #photonics

Here is Tom Le Voyer and Bustamante Jacinta's discovery of inherited ZNFX1 deficiency in patients with monocytosis and BCG-osis or #tuberculosis (pnas.org/content/118/15…)

An exciting collaboration! The sex specific relationship of free carnitine with the severity of cognitive dysfunction found only in women is even more intriguing considering the deficiency of acetyl-L-carnitine (LAC) in both sexes.