Brae M Bigge (@biggebrae) 's Twitter Profile
Brae M Bigge

@biggebrae

Discovery scientist @ArcadiaScience studying proteins across species | she/her

ID: 999798762162843648

calendar_today24-05-2018 23:46:15

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Cameron Dale MacQuarrie (@cdmacquarrie) 's Twitter Profile Photo

🧵 New from Arcadia Science! We used Chlamydomonas mutants to model specific types of spermatogenic failure and found drugs can rescue swimming behavior in mutation-specific ways. Full pub: research.arcadiascience.com/pub/result-chl… [1/8]

Megan Hochstrasser (@thecrispress) 's Twitter Profile Photo

#PubDrop! We've been experimenting with a more scientist-led approach to open publishing at Arcadia Science. After 6 months, here's what we've learned about putting researchers fully in charge of sharing their work… 🧵 1/8 research.arcadiascience.com/pub/result-ear…

#PubDrop! We've been experimenting with a more scientist-led approach to open publishing at <a href="/ArcadiaScience/">Arcadia Science</a>. After 6 months, here's what we've learned about putting researchers fully in charge of sharing their work… 🧵 1/8
research.arcadiascience.com/pub/result-ear…
Prachee Avasthi (@pracheeac) 's Twitter Profile Photo

🚨Job Alert! Help us source the new crop of scientists at Arcadia Science! Are you an independent, generative, rigorous scientist that can pivot quickly? Can you apply your unique skills to a wide range of biological and technological problems? Are you excited to work with

Arcadia Science (@arcadiascience) 's Twitter Profile Photo

Happy Darwin Day! Today we’re thinking about how to use evolution to accelerate biomedical research. We think the answer is to expand the repertoire of organismal models. Search for the best ones using our new portal Zoogle: zoogle.arcadiascience.com/about 🧵

George Sandler (@georgesandler_) 's Twitter Profile Photo

Check out our new pub, "Predicting antimicrobial resistance phenotypes across 7,000 E. coli genomes" where we do a deep dive on AMR evolution in a dataset we previously assembled. research.arcadiascience.com/pub/result-eco…

Justin Donnelly ⌬ (@drjdon) 's Twitter Profile Photo

We found that 48/80, an MRGPRX2 agonist and commonly used mast cell activator, is toxic in HMC1.2 (human mast cells) and RBL-2H3 (rat basophils). Researchers should use caution and incorporate a viability test when performing assays in these cell lines. research.arcadiascience.com/pub/result-48-…

Evan Kiefl (@evankiefl) 's Twitter Profile Photo

1/4 🧵 We analyzed ESM2 and found something counterintuitive: when masking tokens for prediction, the amino acid distributions of residues affect each other in patterns that mirror a protein's 3D contact map. arcadia-science.github.io/2024-paired-to…

1/4 🧵 We analyzed ESM2 and found something counterintuitive: when masking tokens for prediction, the amino acid distributions of residues affect each other in patterns that mirror a protein's 3D contact map.

arcadia-science.github.io/2024-paired-to…
Evan Kiefl (@evankiefl) 's Twitter Profile Photo

1/4 🧵 Excited to introduce "notebook pubs" — a new publication format Arcadia Science is experimenting with that bridges the gap between computational analysis and scientific publication! research.arcadiascience.com/pub/perspectiv…

Justin Donnelly ⌬ (@drjdon) 's Twitter Profile Photo

How did we discover that the widely used mast cell activator 48/80 actually kills mast cells rather than selectively activating them? Here's the surprising story 🧵 (1/12) research.arcadiascience.com/pub/result-48-…

Prachee Avasthi (@pracheeac) 's Twitter Profile Photo

🚨New Job Alert!🚨 We're on the hunt for a new Executive Assistant to work closely with me and with our operations team. This is a full-time, on-site role here at our headquarters in Emeryville, CA. If you want a front row seat Arcadia Science as we build ways to leverage

Evan Kiefl (@evankiefl) 's Twitter Profile Photo

Our team at Arcadia Science took a recent preprint on attention mechanisms for genotype–phenotype mapping, validated the results, improved the performance, and turned it into shareable research in just 9 days. 1/6 🧵 arcadia-science.github.io/2025-geno-phen…

Prachee Avasthi (@pracheeac) 's Twitter Profile Photo

🚨 New job alert 🚨 Our core technologies team is looking for a molecular biology expert to optimize, scale, and deploy our molecular technologies Arcadia Science. Apply now! jobs.lever.co/arcadiascience…

greg (@wright) 's Twitter Profile Photo

We’re looking for our next awesome lab tech to join the Lab Ops team at Arcadia! Apply here: jobs.lever.co/arcadiascience…

Brae M Bigge (@biggebrae) 's Twitter Profile Photo

We’re hiring an *evolutionary cell biologist* Arcadia Science! This is a hands-on role designing and executing experiments across the tree of life, developing methods for measuring and interpreting phenotypes, and helping us test our tools in vivo! Apply➡️jobs.lever.co/arcadiascience…

Prachee Avasthi (@pracheeac) 's Twitter Profile Photo

Another new job Arcadia Science! If you: - are an experimentalist who can work with a range of organisms (including but not limited to unicellular eukaryotes) - can design experiments to test our computational predictions - can do high dimensional phenotyping/data analysis