The public has a distorted view of science, because children are taught in school that science is a collection of firmly established truths. In fact, science is not a collection of truths. It is a continuing exploration of mysteries. - Freeman Dyson

I am thrilled to share the second part of our editorial series on "Quantitation and Error Measurements in Dose–Response Curves," published in Journal of Medicinal Chemistry! A huge thank you to my co-author Matthew D. Lloyd for our ongoing collaboration on this series JMedChem

I am very happy to share this new editorial with Dr Bharath Srinivasan.

My painting TIDAL WETLANDS

Esta es la famosa Foto 51 de Rosalind Franklin, primera imagen del ADN y símbolo de precisión, descubrimiento y mirada al interior de la vida. Esta imagen cambió la forma de entender la vida. Hoy nos inspira a cambiar la forma en que nos mostramos al mundo. #CNBrebranding #DNAday

Thrilled to share our new covalent AKR1C3 inhibitor targeting a non-catalytic tyrosine (Y24) with proteome-wide selectivity! An enabling tool for probing metabolism in hormone-driven cancers. Big congrats to Justin Grams from my team! pubs.acs.org/doi/full/10.10…

We barely understand how life lives. Even though this metabolic map looks impressive, it's just a fraction of the interactions and cycles possible in nature and even these are a gross oversimplification of the nuance at play. This is the goopy chaos I adore.

Reimbursement, pt. 2

Please share! Competitive PhD studentship on Diffuse Midline Glioma and Ferroptosis in my group @ Queen's University Belfast. Deadline = 6th May. qub.ac.uk/courses/postgr…

Thanks for coming. I really look forward to meeting you again Adrian Mulholland

Delighted to share our manuscript Entabolons: How Metabolites Modify the Biochemical Function of Proteins and Cause the Correlated Behavior of Proteins in PathwaysClick to copy article link pubs.acs.org/doi/10.1021/ac…

Excited to share this article sharing my perspective on design principles for irreversible modulator optimisation.

Excited to share a perspective I wrote on the evolving role of irreversible inhibitors in drug discovery published in the JMedChem. I would specifically like to thank Henry Blackwell for his immense contribution. Cancer Research UK , ACS Publications Bio & Med Chem Content

Entabolons: How Metabolites Modify the Biochemical Function of Proteins and Cause the Correlated Behavior of Proteins in Pathways pubs.acs.org/doi/10.1021/ac… Bharath Srinivasan Brice Edelman #JCIM Vol65 Issue11 #Bioinformatics

Covalent inhibitors are characterized by a ratio of two constants. Bharath Srinivasan  explains that considering both, and how one affects the other, could help advance hits on difficult targets: practicalfragments.blogspot.com/2025/07/the-im… JMedChem Cancer Research UK ACS Publications Bio & Med Chem Content

Our story on providing N-OH moities by means of #flavoprotein #monooxygenases for the #cascad# towards N-#hydroxytriazenes just moved online! The promiscuous N-hydroxylating monooxygenase GorA and its application in cascades: Cell Reports Physical Science cell.com/cell-reports-p…

Excited to share our work in JACS. We reveal how tuning transition-state interactions can modulate the binding kinetics of BTK inhibitors. This approach decouples kon & koff from affinity, enabling rational design of reversible inhibitors with enhanced tau & kinetic selectivity

"Resolving Enzyme–Substrate–Activator Ambiguity: A Minimalist Enzyme Kinetic Framework for PROTAC Design and Optimization" pubs.acs.org/doi/10.1021/ac… JMedChem ACS Publications, Science and Innovation at Cancer Research UK Cancer Research UK #PROTAC, #MolecularGlues, #ScienceOfPROTAC, #TargetedProteinDegradation