Pin-Ji Lei, Ethel Pereira, Semir Beyaz, Padera Lab MassGeneral News and colleagues demonstrate that cancer cell MHC-II expression promotes #metastasis and immune evasion in tumor-draining lymph nodes. bit.ly/46dGZk1 #SolidTumors #TumorImmunology

Lymph node #metastasis: An immunological burden. New Insights from Amanda Lund Amanda Lund Lab on the recent study by Lei, Pereira et al. Padera Lab Semir Beyaz (bit.ly/46dGZk1): bit.ly/3XDeFDP #TumorImmunology #BreastCancer

Out today, with Jacks Lab, Isidro Cortes-Ciriano, fmuyas, we used new mouse models of spontaneous lung and colon cancer to delineate a mechanism for why many patients with DNA mismatch repair deficient (MMRd) tumors may not respond to immunotherapy 🧵1/11 nature.com/articles/s4158…

.Padera Lab, Semir Beyaz and colleagues demonstrate that cancer cell MHC-II expression promotes #metastasis and immune evasion in tumor-draining lymph nodes. bit.ly/46dGZk1 From our Tumor Microenvironment & Metastasis collection: bit.ly/3PfWNuV #cshlcancer

How does mitochondria sense and control their glutathione levels? Our new work Science Magazine by a fantastic student Yuyang Liu describing a redox metabolite sensing mechanism for mitochondria. Rockefeller University The Mark Foundation for Cancer Research science.org/doi/10.1126/sc…

#Nutrition got you curious? Join Semir Beyaz for a special Cocktails and Chromosomes this month to find out more! Dishing out the details with plenty of sips. Get your tickets now on Eventbrite! 🍏🥬ow.ly/a7pe50Q5cp2

Come join me tomorrow 11/30 at 6:45pm in Industry at Huntington for cocktails and fun discussion about our research Cold Spring Harbor Laboratory on how what you eat defines who you are!

Lei, Pereira, Padera Lab Semir Beyaz et al. demonstrate that #cancer cell MHC-II expression promotes #metastasis and immune evasion in tumor-draining lymph nodes. hubs.ly/Q02d68vb0 From the Year in Experimental Medicine: hubs.ly/Q02d68NV0

Very excited to share new work from the lab dissecting mechanisms of liver-metastatic organotropism in melanoma and other cancers. Huge congrats to fearless post-doc Meri Rogava (on the job market!) who led this multi-year study! Below a brief summary... nature.com/articles/s4301…

Happy to share our latest preprint in which we uncovered the potential of senolytic CAR T cells to promote tissue regeneration! Wonderful collaboration with Semir Beyaz AmorLab #Senescence #CART #Regeneration. biorxiv.org/content/10.110…

For my friends who don’t want to age, we made something for you: CAR T cells that remove senescent cells in old mice promote stem cell regeneration and tissue fitness in the intestine! Check out our preprint ⬇️

Congratulations to HMS physician-scientist Stuart Orkin, who has been named to TIME’s 2024 list of the 100 most influential people in the world! Orkin’s research has led to the first gene therapy using CRISPR to treat sickle cell disease. #TIME100 time.com/6964969/stuart…

Great opportunity from Semir’s lab 🧪