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Congrats to Sally Hallam from Beggs Lab who carried out the double whammy of passing her PhD viva with minor corrections AND having a paper from it published in SciRep. But what has she found? (Thread)

So it’ll probably get lost in all the noise today on Twitter, but here is our preprint on more than *24,000* samples analysed by Oxford Nanopore LamPORE technology - both symptomatic and a symptomatic patients - finding > 99.5% sens and spec - medrxiv.org/content/10.110…

JOB! There’s not much time left to apply for the Sarcoma Research a fellow job. Do you want to do something different after COVID? We are offering a MD/PhD in sarcoma research backed by a Science and Innovation at Cancer Research UK funded programme. On calls with renal transplant - jobs.nhs.uk/xi/vacancy/916…

Here’s our latest preprint that came out of Tom Nieto PhD thesis Beggs Lab . We’ve found that a long non coding RNA may provide a route to development of dysplasia in Barrett’s oesophagus - well done Tom! medrxiv.org/content/10.110…

Congrats to Robert Tyler from Beggs Lab who has published this early output on the genomics of liposarcoma from the 100K genomes project, integrating WGS, RNAseq and methylation - onlinelibrary.wiley.com/doi/abs/10.100…

Another recent paper using NGS & CyTOF from Beggs Lab - we showed that pathCR in rectal cancer seems to be associated with: 👉⬆️ mutational load and neoantigens 👉⬆️ CNAs but ⬇️ SV 👉Dense CD8+ infiltration Read here - ro-journal.biomedcentral.com/articles/10.11…

Working with ferencmueller we Beggs Lab have branched out into 🐟🐟🐟 by making the most complete zebrafish genome assembly that exists currently using Oxford Nanopore sequencing - resolving the miR-430 repeat locus that was unresolvable using other long read techniques

Exciting news as the paper on RTF-ExPAR, a novel method of amplifying direct from RNA, in as little as 2 mins has landed on PNASNews this evening - led by Jake Carter Jim Tucker and Tim dafforn with help from us Beggs Lab - pnas.org/content/118/35…

Here’s the latest paper that Beggs Lab has helped with lead by the superstar postdoc (who was a PhD at the time) - Regina Andrijes - finding that a tetraspanin seems to provide a RAS independent mechanism for responsiveness to EGFR therapies - pnas.org/content/118/39…

New toy to play with Genomics Birmingham Beggs Lab as we try some @bionanogenomics Saphyr optical genome mapping on blood cancer samples with NHS S&C GMSA Genomics England - contact us for more details if interested…

Molecular characterisation of colorectal cancer related peritoneal metastatic disease. More effective treatments are urgently needed! Great collaborative project at Amsterdam UMC Cancer Center Amsterdam - Amsterdam UMC Oncode Institute SoMe4Peritoneum KWFKankerbestrijding #colorectalcancer nature.com/articles/s4146…

Are you a medical oncologist looking for a job? Do you want to work with us here in Birmingham? We have *THREE* associate professor posts available - apply here: bmj.com/careers/job/15…

Many thanks to Medical Research Council for funding my Senior Clinical Research Fellowship today funding the use of these👇 organoid models to investigate mechanisms of chemoradiosensitivity as part of the foxtrot-study and STAR-TREC trials - to make therapy better and less toxic for patients!

Another Oxford Nanopore sequencing blinder from Jo Stockton in Beggs Lab: Apparently you can't amplify methylated DNA and maintain the methylation - well you can! Top sample - conventional WGA Middle sample - methWGA Bottom sample - original sample

Explore alterations in #cancer driver genes in patients with #cholangiocarcinoma with Beggs Lab, Javier Herrero, Ian Tomlinson, Juan Valle, John Primrose & John Bridgewater at #ASCO23: bit.ly/3OSON4r #CRUKFunded

Sequenced by Beggs Lab - with: 👉 RNA extraction using Covaris NA extraction 👉 QIAGEN Life Sciences DNA and RNA multimodal NGS panel 👉 Custom UoB Advanced Research Computing (BEAR) pipeline based on Nextflow It’s not easy but we are getting better at sequencing these historical samples

BILCAP Sequenced by Beggs Lab - with: 👉 DNA & RNA extraction using Covaris NA extraction 👉 QIAGEN Life Sciences DNA and RNA multimodal NGS panel 👉 Custom UoB Advanced Research Computing (BEAR) pipeline based on Nextflow It’s not easy but we are getting better at sequencing these historical samples

ONCOLOGISTS - we have an associate prof post available! Work with us in Birmingham and get access to one of the largest Oncology units in the UK More details in my LinkedIn post here - linkedin.com/posts/andrew-b… Or job is here: edzz.fa.em3.oraclecloud.com/hcmUI/Candidat…

Congrats to Ollie (not on twitter) part of Gary Middletons group and Beggs Lab !

We had a good day - really proud to be part of this important UK and Spanish consortium to futher Bowel Cancer research for the next 5 years! Great team (L-R) of Beggs Lab Jenny Seligmann Philip Dunne Trevor Graham CRUK National Biomarker Centre Simon Leedham Owen Sansom 🏳️‍🌈, Crispin Miller,