Excited to unveil today CRISPR-CLEAR at #ASHG23, our new CRISPR screen modality to decode genotype-phenotype relationships at nucleotide & variant-level resolution. Join us at Conv Ctr/Ballroom A/Level 3, 2:15pm-2:30pm. #Genomics #CRISPR

with biomedical PhD apps due soon, I get a lot of requests for help/advice this time of year. From my own experiences and including others' resources, I made this guide that I use to lead workshops, but also stands alone as a resource. Please share! yaelcourtney.com/phdapplication…

Undergraduate professors, if you have a talented senior college student with quantitative reasoning/computational chops interested in upgrading medical care with artificial intelligence consider recommending the AI in Medicine PhD track at Harvard Medical School: dbmi.hms.harvard.edu/education/phd-…

I've been using the new shareable link feature in Illustrator a ton. Very convenient for collaboration helpx.adobe.com/illustrator/us…

Nice paper that provides a framework for high MOI screens. Does build on previously established high MOI Perturb-seq methods used to reduce cost, i.e. Gasperini et al Cell 2019, SCEPTRE (Barry et al Genome Bio 2021), etc

If I was to have a superpower, it would be to write working code on the first try.

If you are serious about learning programming, I'd suggest starting with a strongly-typed object-oriented language such as Java. After that, can learn Python in probably a weekend. Python/R was meant to be convenient, so bad practices will be learned.

Highly recommend, both entertaining and informative to see how great scientists think

⌛️ 2-week countdown: Applications for our PhD in Biomedical Informatics program — both the AI in Medicine (AIM) Track and Bioinformatics and Integrative Genomics (BIG) Track — are due December 1! dbmi.hms.harvard.edu/education/phd-…

A wonderful read about Stu Orkin and Daniel Bauer and the road to Casgevy, a landmark for medicine and gene editing. Collaborating with Dan and Stu was a highlight of my professional life and I personally will forever be in their debt for choosing to work with my team.

This week we held our Third Annual GRO Retreat Broad Institute and it was a blast! Thank you to our keynote speaker Benjamin Ebert, our visiting speaker Sara Mostafavi & all of our contributing discussion leaders, breakout participants, poster presenters. An incredible group!

The BMI program retreat was in Provincetown this weekend. Among other activities, students were treated to our guest speaker Robert Gentleman, Director of the Center for Computational Biomedicine at HMS.

Understanding genomic variation is no easy task! I’m thrilled to be part of a fantastic team in the National Human Genome Research Institute-funded IGVF Consortium, working together to tackle this mission. Check also out our paper where we outline our goals and challenges: #IGVF nature.com/articles/s4158…

First pre-print from the lab! Together with Luca Pinello and Daniel Bauer we developed CRISPR-CLEAR, an experimental and computational pipeline to dissect enhancers at nucleotide resolution. biorxiv.org/content/10.110…

Excited to share our work "CRISPR-CLEAR", an end-to-end workflow for dissecting enhancers at nucleotide resolution! Check out our pre-print and Davide Seruggia's tweetorial below! Lead with Sandra Wittibschlager and Zain Munir Patel and labs Luca Pinello Davide Seruggia and Daniel Bauer.

This is phenomenal. The initial collaboration between Daniel Bauer and yours truly used the kernel of this approach to discover the GATA-1 site in the BCL11A enhancer - nature.com/articles/nmeth… - to see this scaled up by many logs is nothing short of thrilling.

Come to our booth to learn more about the Harvard BIG PhD program! #SACNAS2024 #NDiSTEM