Excited to have just presented at #ECTRIMS2024 our work showing that thalamic atrophy at baseline predicts PIRA in early-MS. These patients show microstructural damage in the thalamus near the ventricle, supporting CSF-mediated damage hypothesis. Cemcat Angela Vidal-Jordana

Müller Jannis: MSBase register study in de-escalation of treatment in #MS. Increased risk of relapse reoccurring remains 2.3x higher. No real cutoff for age, EDDS, disease duration or time from last relapse was found. Note: Most were on natalizumab in this study! #ECTRIMS2024

Abdelhak: effect of fingolimod and anti-CD20 treatment on sGFAP (z-scores) evolution & subsequent effect on PIRA in RRMS pts. Lowering Z-GFAP in first two years of treatment decreases PIRA risk in subsequent years by 44 (aCD20)-55%(fingo) sNFL does not add effect #ECTRIMS2024

Kowalec (US) effect of genetic predisposition for depression on disease activity in #MS. Higher risk of relapse and EDSS progression in persons with higher predisposition for depression! Importance of comorbidity on MS disease course! #ECTRIMS2024

Chataway (UK): MS-stat2 study on simvastatin 80mg vs placebo in SPMS. Large phase 3 trial, unfortunately no significant effect on confirmed progression 🤷🏻‍♂️ #ECTRIMS2024

Jiwon Oh (US): tolebrutinib vs teriflunimode in RRMS (GEMINI trials). - ARR : no difference! - 6m CDW: 29% reduction on tolebr - 3m CDW: 27% reduction on tolebr - New Gd+ lesions are higher on tolebrutinib! - T2 lesions: no difference - good safety profile #ECTRIMS2024

Lebrun-Frenay: Preventive healthcare in multiple sclerosis will need to focus on lifestyle and Epstein-Barr vaccination. #ECTRIMS2024

De highlights van #ectrims2024 Dag 2. youtu.be/Xm-u4fl6wvo?si…

Ook voor #ectrims2024 Dag 3 overloop en verduidelijk ik kort de belangrijkste topics (met een mooie afsluiter) in een korte video. youtu.be/ULSfrX42W4k?si…

Professor Giancarlo Comi stressed the importance of listening to individuals with MS, pointing out that their experiences are a crucial tool in assessing disease progression. Read ECTRIMS’ tribute to his extraordinary legacy 👉 bit.ly/3B1xFFc #MSResearch #Neurology

What a big legacy, what a great researcher, what a great teacher, what a great visionary, what a great man… a true example and inspiration. We will miss you dearly. RIP 😔

Best wishes for a wonderful 2025! May peace, love, good health and joy be your constant companions #happynewyear