Part of my MSc thesis was published!

We are looking for a new colleague! The Laboratory of Biochemistry has a vacancy for a staff scientist proteomics expert. Come join us :D wur.nl/nl/vacature/se…

I am very excited and grateful to be awarded a Vidi grant to further consolidate the Argonaute research in my group! Many thanks to everyone who made this possible. Vacancies for PhD and PD positions will be posted soon :)

❗️preprint alert!❗️ Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA biorxiv.org/content/10.110… We are excited to share our newest study where we uncover how the SPARTA immune system is activated! 🧵(1/14)

This story is finally out! Was happy to contribute during my MSc

The long-expected manuscript on the characterization of catalytically inactive long-b pAgos. Like short pAgos, they act together with (variable) associated effector proteins. Great work! nature.com/articles/s4146…

Super proud on Balwina Koopal , who successfully defended her PhD thesis "short and sweet, on short pAgos", and was awarded with a cum laude PhD degree! Excellent thesis, defense, and defense party ;) Bel is the first PhD graduating from my group. Thanks for the adventure Bel!

Paper out today: “RNA-guided RNA Silencing by an Asgard archaeal Argonaute”. A wonderful, multidisciplinary project co-led with Daan C. Swarts Joo_Lab, spearheaded by Carolien Bastiaanssen Pilar B U Kijun Kim @FinocchioGiada & Yanlei Feng. nature.com/articles/s4146… Nature Communications

Cell walls are crucial in all aspects of plant life, yet challenging to study. PhD Maarten Besten, our chemistry superman, likes a challenge and designed a modular probe toolbox for live 5D plant cell wall imaging. We present: CarboTag. A 🧵 biorxiv.org/content/10.110…

New paper alert by LOlijslager ! academic.oup.com/nargab/article… "Distribution of specific prokaryotic immune systems correlates with host optimal growth temperature" A 🧵

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

v1.2.0 of BindCraft released on github. Includes improvements to the Colab notebook, new design protocol options, several critical bug fixes in the run script, QoL improvements, and streamlining of the installation script.

Such a powerful protein binder design pipeline, and now with even more useful applications! Like guiding AAVs to specific cell surface receptors, neutralizing allergens, and inhibiting nucleases like Cas9 and pAgo!

This is 🔥🔥🔥! Martin Pacesa, Lennart Nickel, Bruno Correia Sergey Ovchinnikov, et al. developed BindCraft - an open-source pipeline to design de novo binders for basically any protein of interest. We asked if we could design binders for CbAgo - a DNA-guided DNA interfering Argonaute..

Out now in Molecular Cell: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-cell… Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein? A 🧵