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Just some new actin probe we are working on currently. Great for #live_cells, #confocal or #STED, no verapamil needed, low phototox and cytotox. (Here imaged over 48 h, every 30 s) #FluorescenceFriday

I hope this story gets shared widely! Luc BUEE Duff Lab SpillantiniLab Juergen Goetz Michel Goedert David Holtzman Martin Kampmann Gan Lab Bess Frost

Move over APOE3 Christchurch—a new protective variant has arrived. A point mutation in the ApoE receptor-binding Reelin enabled two siblings to stave off their autosomal-dominant #Alzheimers for 20 years past expected age of onset. Universidad de Antioquia MassGeneral News ow.ly/vMkl50OpK6I

Clinical relevance of animal models in aging-related dementia research We just published a Perspective in Nature Aging, making a case for using animal models in Alzheimer's research

Our Perspective in Nature Aging making a case for using animal models in Alzheimer's research is now online - thank you, Pranesh!

Timothy Keller, a New York-based Christian apologist and source of inspiration, died May 19. My thoughts are with his family. christianity.com/wiki/people/ti…

The #FUSFoundation had its 2nd FUS-AD (#Alzheimer's disease) workshop since 2015 in Washington DC, close to the Arlington airport. Coming up with recommendations how to move the field forward and going home inspired. Thank you, #FUSFoundation.

Fundamental research is not driven by commercial/practical considerations, but by sheer scientific curiosity. This type of research has laid the foundations for many of today's most important innovations. Modern economies can't afford to invest exclusively in applied research.

Focused #ultrasound mediated blood-brain barrier-opening study in #Alzheimers disease patients by Ali Rezai's team suggests the existence of a brain-wide perivenous fluid efflux route in humans.

Huge congratulations to Adam Briner - my first student cosupervised with Juergen Goetz to graduate. He has accepted the Azrieli postdoctoral fellowship and will join Weizmann Institute in November.

Our study showing that ATFS-1 acts as a molecular switch to prioritise mtDNA repair over expression, thereby reducing age-dependent mtDNA damage, is out today in Nature Cell Biology ! Congrats Michael on your paper! Michaeldcy Queensland Brain Institute, UQ nature.com/articles/s4155…

Brain Ponderings Podcast: Pondering Ultrasound Treatments for Neuromodulation and Brain Disorders with Jürgen Götz Spotify: open.spotify.com/show/39HsoeK8o… Youtube: youtube.com/@brainponderin… Interviewed by Mark P. Mattson, former Chief of the Lab. of Neuroscience at NIH

Warm congratulations to my senior postdoc and Research team leader "Exosomes and tau pathology", Dr Juan Carlos Polanco, who has been invited to speak in Rome on the role of extracellular vesicles and underlying mechanisms in neurological disorders and brain injury.

Looking forward to this inaugural meeting in Brisbane later this year, celebrating cellular and molecular research in the dementia space CAMAND

Fatty acids hold clue to creating memories - congratulation to Fred Meunier's team at CJCADR/QBI embopress.org/doi/full/10.10…

Where does tumor antigen go after histotripsy? Our new Theranostics paper shows it complexes with DAMP(s), flows to the lymph node, and activates the cDCs that gobble it up. Critical info for optimizing FUS & immunotherapy. thno.org/v14p1647.htm Focused Ultrasound Foundation Virginia BME

We are pleased to announce a new publication (Leinenga et al., Molecular Psychiatry 2024) from our team which shows in Alzheimer's mice that ultrasound on its own, without blood-brain barrier opening and in the absence of clearing amyloid, can improve cognitive functions.

I am pleased to advise that our team as CJCADR/QBI has been successful in incorporating ASTU Inc. (AUSTRALIAN SOCIETY FOR THERAPEUTIC ULTRASOUND) 🙂

nytimes.com/2024/04/21/opi… Inspiring article about Leviticus and Passover on NYT

Published in Brain: doi.org/10.1093/brain/… Our new data suggest that anti-Tau immunisation works towards restoring homeostasis, presenting quantitative proteomics as a viable strategy to validate therapeutic interventions in preclinical models.