Science has a sustainability problem. 53eig.ht/2IJMVIL

New research from Chen et al. "DART-ID increases single-cell proteome coverage" plos.io/2YGfFb5

A dream of single-cell proteomics bit.ly/sc_proteomics w/ C.Vogel New York University Slavov Laboratory Northeastern U., R. Aebersold @eth PeterK Harvard Medical School J. Cox Max Planck Institute of Biochemistry (MPIB) @Rune_Linding @Humboldt_Uni

The revised version of SCoPE2 biorxiv.org/content/10.110… has 3 major improvements: 1) SCoPE2 data for >1,000 single cells. No, the reviewers didn’t ask for it, but we thought it's a good way to characterize the reproducibility and throughput, much better than adjectives. 1/4

Our paper is out on bioRxiv describing our SARS CoV2-human protein-protein interaction map and drug predictions from the data. It was a honor to work with so many fantastic scientists around the world. -Nevan biorxiv.org/content/10.110…

Heads up on a 2-day all-star ASGCT COVID-19 symposium starting tomorrow. Dr Fauci is the opening keynote. Albert Chen DevermanLab Shing our group is giving the last talk on Wednesday afternoon 5:15PM CDT! asgct.org/events/covid-s…

Our talk just got bumped earlier to 5 PM CDT / 6 PM EST. The closing talk for the ASGCT COVID-19 symposium. Grab your happy hour drink of choice and tune in for our 15-min talk! 🍻🍷🧋🍵🍼🧃🥤🍾🍸🥂🍹🧉🥛🧬 webcastregister.live/asgct_covid19_…

I’m delighted to share the first emmottlab preprint! In this paper we study protease activity in #SARSCOV2 infected cells. We found multiple unknown cleavage sites in viral proteins, and novel cellular targets of the viral proteases essential for virus replication.

New paper: Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2. genomebiology.biomedcentral.com/articles/10.11… now published in Genome Biology

Our joint single-cell analysis of proteins & RNAs in differentiating macrophages appeared in Genome Biology genomebiology.biomedcentral.com/articles/10.11… (preprint: biorxiv.org/content/10.110…) We analyzed ~ 3,000 proteins and RNAs across single monocytes and macrophages, and found ...

We’ve updated our SARS-CoV-2 preprint investigating proteolysis by viral and host enzymes during SARS-CoV-2 infection! Lots of new data, and an author list now covering 4 countries on 3 continents! Read it here: biorxiv.org/content/10.110…

We've created an interactive website to visualize >100,000 experimental measurements of how mutations to #SARSCoV2 RBD affect binding by antibodies & sera: jbloomlab.github.io/SARS2_RBD_Ab_e… Explore it to examine a wealth of information about the antigenic effects of viral mutations. (1/n)

My awesome sister just released her book! Uplifted tells the personal stories of how 21 Asian American entrepreneurs built their businesses, overcame their greatest challenges, and drew strength from their identities to uplift others. kickstarter.com/projects/uplif…

And its out! My/@Emmottlab first PI paper “Characterising proteolysis during SARS-CoV-2 identifies viral cleavage sites and cellular targets with therapeutic potential”. nature.com/articles/s4146… This was a huge collaborative effort with 19 authors spanning 4 continents!

1⃣Developing a method is just the first step. ✔️ 2⃣Helping others adopt it is the second step 👇 Thanks to Aleksandra Petelski, Ed Emmott and the entire Slavov Laboratory team for this Nature Protocols article! nature.com/articles/s4159…

We have released a preprint “Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions”. We developed gene delivery vectors with known mechanisms of action & predictable tropisms by targeting AAVs to specific proteins. tinyurl.com/2ndsuvp6