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In patients with inborn errors of metabolism undergoing cord blood transplant, individualized rATG dosing by weight and absolute lymphocyte count led to early CD4+ recovery, low acute #GVHD (7%), and 83% survival. Explore the full study: astctjournal.org/article/S2666-…

New research highlights how age, conditioning intensity and acute #GVHD impact thymic recovery after #alloHCT in children with inborn errors of immunity. Measuring recent thymic emigrants may guide personalized strategies to improve outcomes. Read more: ow.ly/cNrN50VNaGT

Discover the newly redesigned ASTCT Practice Guidelines App— your go-to clinical tool, now better than ever. Download it now: astct.org/Education/Prac… ASTCT #ASTCT #PracticeGuidelineApp

The May issue of 'Transplantation and Cellular Therapy,' is now available online. Check out the latest research in transplantation, cellular therapy and more: astctjournal.org/current Elsevier Hematology

New research from the Spanish PETHEMA AML registry evaluated the front-line role of #autoHSCT or #alloHSCT as treatment for secondary acute myeloid leukemia patients (sAML). Findings reinforce that #alloHSCT remains the sole potentially curative option. astctjournal.org/article/S2666-…

ICYMI: We have released a new supplement dedicated to the latest research, challenges and innovations in Tumor-Infiltrating Lymphocyte (#TIL) therapy, supported through an educational grant provided by Iovance Biotherapeutics. Access the supplement: ow.ly/MviL50VlXTi

Transformative therapies are changing the outlook for adults with sickle cell disease. This article compares options like matched sibling transplants, gene therapy and haploidentical BMT. Each approach offers benefits, and now, for many, there’s a choice. astctjournal.org/article/S2666-…

This retrospective analysis suggests that granulocyte colony-stimulating factor–primed bone marrow (G-BM) grafts are associated with prompt engraftment and low #GVHD rates. They are safe for donors and simplify harvest by reducing collection volumes. astctjournal.org/article/S2666-…

New findings from the RESILIENT Conference highlight how chronic #GVHD and corticosteroid exposure after pediatric #HCT can drive early endocrinologic, cardiometabolic and vascular complications. Early screening and intervention are key to survivorship. ow.ly/OcU350VV97I

A new single-center study finds plasma nucleosome levels rise 4 weeks after #alloHSCT and are inversely associated with later development of acute #GVHD. Beginning on day 28 and onward, nucleosome and CRP levels were also positively correlated. Read more: ow.ly/v4vk50VV9aN

This study outlines the co-design of a novel ordinal endpoint for BANDICOOT—an adaptive platform trial in pediatric #HCT. The endpoint combines organ support, viral reactivation and immune reconstitution. Read more: astctjournal.org/article/S2666-…

In the third episode of ASTCT Talks’ exclusive 8-part series, supported by an educational grant from Sanofi US, Dr. Corey Cutler speaks with Dr. Steven Pavletic on the role of lifestyle medicine in chronic #GVHD, an emerging area in transplant care. ow.ly/4eHS50VV9fN

A new study evaluates the Immunodeficiency Scoring Index (ISI) in #alloHCT recipients with RSV. A high-risk ISI predicts lower respiratory tract disease and 100-day mortality, with HLA mismatch and severe lymphopenia as key factors. Read more: astctjournal.org/article/S2666-…

A new study shows influenza-specific T-cell responses can be induced before #CART therapy, even without antibody response, and may persist after infusion. Findings support vaccination at least two weeks before lymphodepletion. Read more: astctjournal.org/article/S2666-…

A recent ASTCT survey finds most physicians support using geriatric assessment (GA) before #HCT or #CART therapy in older adults, but face barriers like limited time and staff training. Read the full article: astctjournal.org/article/S2666-…

This retrospective analysis study finds that while about one-third of IDH-mutated #AML patients relapse after transplant, overall survival outcomes remain relatively promising. IDH1 mutations are linked to higher relapse and lower event-free survival. astctjournal.org/article/S2666-…

This study compared the cost-effectiveness of “immediate” vs. “late” #CART as second-line therapy for DLBCL. While “immediate” CAR-T is generally cost-effective, real-world factors, like age and quality of life, may favor a “late” approach. Read more: astctjournal.org/article/S2666-…

The updated ASTCT Practice Guidelines App makes it easier than ever to access clinical tools, GVHD scoring, built-in calculators and more—right at your fingertips. If you haven’t downloaded it yet, now’s the time: astct.org/Education/Prac…

Two nonmyeloablative HLA-matched #alloHCT regimens for severe sickle cell disease show high survival and stable mixed myeloid chimerism. Read the full study: ow.ly/Zmcx50W2AiY

High amphiregulin (AREG) expression was found in intestinal biopsies of pediatric patients with severe #GVHD and IBD. AREG levels correlated with inflammation severity, suggesting its potential as a biomarker for severe GVHD in children. Read more: ow.ly/Fwmo50W2Al9