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Q13 Ashley Mutchler Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Lale Ertuglu, MD You have seen an association between IsoLv activation of APCs and pro-inflammatory cytokines in salt-sensitivity. Are these changes are associated with changes in vascular function or structure in your cohort? #HYPHIP Hypertension

Guto Montezano Ashley Mutchler Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Hypertension A13 1/2 This is a great question. Dr. Laffer and colleagues previously showed that salt sensitivity is associated with increased vascular resistance, suggesting that vascular dysfunction plays a key role in salt sensitivity. Hypertension #HYPHIP

Guto Montezano Ashley Mutchler Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Hypertension A13 2/2 While we could not assess vascular function in the current study, previously Meena Madhur David G Harrison found that T-cell activation and IL-17A production lead to vascular dysfunction by altering vascular reactivity and increasing vascular superoxide Hypertension #HYPHIP

Guto Montezano Ashley Mutchler Lale Ertuglu, MD Hypertension A14 salt-sensitive people have super sensitive and high expression of SGK1. Our data indicates not through the MR. It’s the GR. Aldo does not correlate with salt-sensitive hypertension #HYPHIP Hypertension

Lale Ertuglu, MD Guto Montezano Ashley Mutchler Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Hypertension Meena Madhur David G Harrison Did see differences in pulse pressure as a crude estimate of arterial stiffness? #hyphip Guto Montezano Hypertension Lale Ertuglu, MD Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A.

Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Ashley Mutchler Lale Ertuglu, MD Hypertension These APCs express little to no MR unfortunately 😊

Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Guto Montezano Ashley Mutchler Hypertension In our previous study using CITE-sequence analysis, we found no significant change in the expression of any RAAS-related gene in APCs after salt loading and depletion. Hypertension #HYPHIP Guto Montezano frontiersin.org/journals/physi…

Francisco Rios Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Ashley Mutchler Hypertension Guto Montezano A12 Yes both innate and adaptive immunity appear to play key roles! This is a very interesting point to look into in future studies! Francisco Rios Hypertension #HYPHIP

Ashley Mutchler Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Lale Ertuglu, MD it was amazing having you here with us today and congrats on your paper. I am looking forward to more from you all and get to see all your salt studies and other ones as well! A heartfelt thank you and I hope you enjoyed the chat! #HYPHIP

Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Ashley Mutchler Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Hypertension Meena Madhur David G Harrison We did not see a difference in baseline pulse pressure between salt-sensitivity tertiles, but pulse pressure significantly decreased from salt-loading to depletion in salt-sensitive people compared to salt-resistant Hypertension #HYPHIP

Guto Montezano Francisco Rios Ashley Mutchler Lale Ertuglu, MD Q12 - in our initial paper published in jci we performed a comprehensive analysis and found IsoLgs as extremely potent compared to other lipid mediators #HYPHIP Hypertension

Our summer research med student @Tinich_tmed presenting his amazing work as part of the @vumcdiabetes summer research and training program! Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. #KiraboLab #NIDDK

Excited to share our research manuscript "ET-3/ETBR Mediates Na+-Activated Immune Signaling and Kidney Lymphatic Dynamics" Published in Circulation Research ahajournals.org/doi/10.1161/CI… Congrats #KiraboLab 1st author Ashley Mutchler & co-authors @EShelton24

Happy Holidays from the #KiraboLab! We’re grateful for scientific discoveries, meaningful collaborations, and the brilliant minds that make it all possible. Here’s to a joyful & restful holiday filled with love and inspiration for the year ahead! 🧪❤️ #Gratitude #ScienceFamily

Thrilled to see our paper featured on the cover of @circres! 🎉 #ET-3/#ETBR signaling in #lymphatic vessel dynamics as a novel player in #kidney disease pathogenesis - potential therapeutic target. Read more: ahajrnls.org/3WoU9az ashley pitzer zhongzhong @EShelton24

What better way to start out my new position as Assistant Professor at Meharry Medical College than an issue featuring our cover art, research article, and invited review (both as 1st and corresponding author!). Meharry Medical College @MeharrySOGS @merrylindseyphd Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A.

Beyond excited about this review article where we overview Epigenetic Regulation of Innate and Adaptive Immune Cells in SSBP & discuss ongoing research in my lab of IsoLG-modified histones as potential epigenetic regulators! Circulation Research @MeharrySOGS @merrylindseyphd Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A.

Access to excess dietary sodium has heightened the risk of cardiovascular diseases, particularly affecting individuals with salt sensitivity of blood pressure.… Congrats ⁦Ashley Mutchler⁩! 1st & Corresponding author invited paper ⁦Circulation Research⁩ search.app/zfFQGBSWB4hpVF…

🎉 Huge thanks to ⁦Circulation Research⁩ outstanding reviewers including former #KiraboLab trainee ⁦Ashley Mutchler⁩ now Assistant Professor ⁦Meharry Medical College⁩ ⁦@MeharrySOGS⁩! Your commitment to scientific excellence continues to shine. #ProudMentor #WomenInSTEM ⁦

Our paper "Moving toward a better understanding of renal lymphatics: challenges and opportunities" published in #PediatricNephrology is now in pubmed PubMed Trending pubmed.ncbi.nlm.nih.gov/39899153/ Thanks Dr. Kon for including us on this! Ashley Mutchler @EShelton24