New work from Richard Border and others (including myself and Andy Dahl) that develops a computationally efficient software package, xftsim, for forward simulation of complex intergenerational dynamics including both genetic and cultural transmission from parents to offspring.

New preprint! With a large group of Swedish colleagues, we present a vision for Precision Omics Initiative Sweden, PROMISE, to build powerful national research data resources, and a research, healthcare and innovation ecosystem around them. 1/ papers.ssrn.com/sol3/papers.cf…

"Even if we only consider the 68 clinical variants suggested by the TPMI expert panel, 89.7% of the variants have RD < 5%. Similar results were presented in a previous study using BioMe and UK Biobank, where 89% of the variants have RD < 5%" medrxiv.org/content/10.110…

Please re-tweet: We are hiring! Assistant Professor in statistical genetics. Also, hiring a postdoc. Reach out to hear more. Also, if you’ll be at #ASHG24 #ASHG2024, we could meet. careers.ashg.org/jobs/20762543/…

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at lpshg.com

I wrote about the ongoing debates over genomic data sharing and the use of such data for "abhorrent science", including some perspective papers that came out last month. A few key points: 🧵

Thrilled to receive the Presidential Early Career Award for Scientists and Engineers (PECASE)! Could not have done this without my amazing lab members and mentors. whitehouse.gov/ostp/news-upda…

A big win for Parse, our customers, and the research community! Filing meritless lawsuits is not the way. Very proud of our team at Parse, and I’m looking forward to sharing more exciting science, partnerships, and product news over the coming weeks and months!

Beyond excited to share this new paper with all of you . It's the most fun we've ever had. We figured out how to study a latent index driving partner choice without measuring it directly🥂 Qinwen Zheng Preprint📰: biorxiv.org/content/10.110… Sumstats⬇️: qlu-lab.org/data.html

We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in Nature Communications today: nature.com/articles/s4146…

1/ 🧬 A Hitchhiker’s Guide to Long-Read Genomic Analysis is out now Genome Research! This mini-review walks through the latest advances in long-read DNA sequencing — from assemblies to variant calling to epigenetics. Link 🔗 genome.cshlp.org/content/35/4/5… 🧵👇

Racism twitter has taken to arguing that observed racial differences must be "in part" explained by genetic differences, though they demure on how much. Not only is this claim aggressively misleading, it is completely unsupported by data. A 🧵:

New perspective out now in Nature Genetics! nature.com/articles/s4158… We argue that current variant classifications oversimplify disease risk and propose an integrated Bayesian framework that unifies pathogenicity & penetrance.

A more complete understanding of human genetics starts with accurate, high-quality reference genomes. HPRC is building a reference that reflects the breadth of human genetic variation, supporting better prediction, diagnosis, and treatment. Learn more: humanpangenome.org/samples/

People often intuitively interpret genetic ancestry PCA plots as simple genetic distances, but this is not always the case. Below are random pairs of individuals that are far apart in PCA space (lines) but actually have fewer total variant differences (numbers).

I’d love to hear biologists weigh in on the fundamental question: can you predict the impact of cell perturbations better by studying the natural variation in a population of healthy cells (more data), or by studying cells that have been perturbed genetically or chemically?

A few thoughts on Herasight, the new embryo selection company. First, the post below and the white paper imply that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

Hot off the press Neuron "From variants to mechanisms: Neurogenomics in the post-GWAS era" Genetic architect -> biological mech for ASD/SCZ/AD Major effort led by MSTP student Michael Margolis + great collab w/ Michael Ziller & Naomi Wray bit.ly/4oSunr1

The second major chunk of my Ph.D. is now online in Genome Biology! Brief recap: 🧵 genomebiology.biomedcentral.com/articles/10.11…