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(1) We are excited to finally share “Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy” at Science Translational Medicine (bit.ly/4b23Gdq). SNAF is an end-to-end workflow for splicing neoantigen & transmembrane epitope prediction...

I am really pleased to share our latest manuscript, just published nature! You can access the manuscript (open access) here: nature.com/articles/s4158… Special thanks to Maria Carolina Florian for the great commentary: nature.com/articles/d4158…

🚀 Launching our #SingleCellAtlas: a deep dive into human bone marrow with paired CITE-seq and high-dimensional flow cytometry! Led by Xuan Zhang and Annie Song published in Nature Immunology. doi.org/10.1038/s41590… 1/3

Check out our digital resource for everyone in #hematology! altanalyze.org/MarrowAtlas/ Visualize any gene and surface marker on 80+ cell states from >400k human HSPCs from donors spanning race and sex. Check the Infinity Objects for isolation strategies of your cell of interest. 2/3

This is team science! 🤝 A big shoutout to Lee Grimes Lab, Diane Krause, University of Pittsburgh (Singh lab) & Jordan Lab. Funded mostly by an RC2 grant from NIH, NIDDK, Shilpa Hattiangadi. Kudos to BioLegend, Cytek Biosciences & Curiox Biosystems for their support with prototype products! 3/3

Excited to announce our Human Bone Marrow Progenitor Atlas (doi.org/10.1038/s41590…). >80 rare stem/progenitor states delineated through multimodal (CITE-Seq) integration w/ prior cell atlas labels (scTriangulate). Validated by InfinityFlow, sorting & in vitro differentiation.

We provide an interactive web portal for supervised classification and cell surface marker imputation (Azimuth), multimodal CITE-Seq ShinyCell browsers and donor expression viewers at altanalyze.org/MarrowAtlas/. Collaborators Lee Grimes Lab Diane Krause Jordan Lab Singh lab

AND.....special thanks to Kathrin Bernt insightful review of our latest atlas paper! 🌟 nature.com/articles/s4159…

Our Human Bone Marrow CITE-Seq Portal (altanalyze.org/MarrowAtlas/) now hosts video and step-by-step walk through tutorials for: 1) Supervised scRNA-Seq annotation (Azimuth) 2) Comparative visualization of RNA & ADTs (ShinyCell). Please see the on-page and Synapse download links.

Very proud that our discovery that phophoserine RUNX1 promoted megakaryocyte (MK) fate specification in primary human MEP is out! YaleCCEH Yale Lab Medicine Work of many including the amazing Nayoung Kwon sciencedirect.com/science/articl…

Previous studies have shown self-reported Black patients have inferior treatment and survival outcomes compared to White patients, but why? Our work indicating that underlying genetics influence AML biology is now live at NatureGen! 🎉🎈🍾 nature.com/articles/s4158…

Proud of all authors of our paper showing RUNX1 is activated by CDK9 to promote megakaryocyte fate in primary human progenitors. Let us know what you think! Nayoung Kwon Evrett Thompson Rubia Mancuso @Yalelabmed Yale Lab Medicine RUNX1 Research Program authors.elsevier.com/a/1j%7EX21UYwn…

🎉Excited to present our latest work out today nature 1.What gives a leukemia its phenotype – the oncogenic driver or the differentiation stage of the cell-of-origin? 2.Why do RAS mutations always happen late in AML? 3.Who will relapse after VEN? nature.com/articles/s4158…