Excited to share some new work with Layton Rosenfeld (an amazing former intern in our group). Our microbiota can evolve w/in us in real time. Here, we ask how this ongoing evolution influences (or is influenced by) the ecological structure of the surrounding community.

We opened a position for a postdoctoral researcher to work on computational and population genetics approaches to study mutation and selection processes. Excited candidates can e-mail me for more information or apply here: recruitment.crg.eu/content/jobs/p… Thanks for RTing!

Excited about cancer genomics, translational data science and machine learning? We're recruiting! Multiple postdoc and scientific programmer positions open at our site at the University Hospital Cologne! jobs-uk-koeln.de/index.php?ac=j… PM me for further details.

Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. biorxiv.org/content/10.110… Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm

💥Apply for a PhD at #CRG! Join a center of excellence with teams representing a broad range of disciplines, 1st class core technologies, high-profile seminars & a comprehensive training programme #PhDCRG23 We offer 14 fully funded #PhD fellowships: bit.ly/PhD23 ⬇️⬇️

Very excited to share that I recently started my lab in The Halvorsen Center for Computational Oncology at Memorial Sloan Kettering Cancer Center! Looking for postdocs and graduate students interested in cell fate decisions/cancer evolution/computational single-cell genomics. Come join us in NYC! Spread the word & please #RT. Thanks!

Happy to share our work exploring the role of A/T-ending codons across species, tissues, development, gene families and protein complexes🧬🦧🧠 👉bit.ly/cellsystems Centre for Genomic Regulation (CRG) serranoLab with Manuel Irimia Donate Weghorn Martin Schaefer #codonusage #rasgenes Cell Systems

We extend the Walsh-Hadamard transform to accommodate multiallelic genetic landscapes & show this new theory enables the inference of models that reflect biological mechanisms even when data is scarse w/ Ben Lehner Vero Claudia Serrano Donate Weghorn biorxiv.org/content/10.110…

Do you enjoy approaching complex phenomena with models and maths? I am looking for a PhD Student: ➡️ exciting science: modelling variation & evolution ➡️ excellent environment Barcelona Collaboratorium Centre for Genomic Regulation (CRG) ➡️ lnkd.in/e66VT6J3 Please retweet.

Have you, like us, ever been frustrated with mutational signature refitting results on samples with few mutations? Then you may find our new algorithm, SigNet, useful: biorxiv.org/content/10.110…

In this fun collaboration with the excellent people from the Berg lab, using two tumors with high-resolution sampling, we found that tumor growth takes place throughout the tumor volume rather than just at the surface: biorxiv.org/content/10.110…

🔬👩🏿‍💻 For a PhD, choosing right is not only about research, it’s also about the people and the location, and we have it all! ➡️Apply for a fully funded PhD fellowship at #CRG in Barcelona, 17 PhD positions available! 👉🏿 tinyurl.com/CRGPhD24

We are looking for Independent Faculty to join the Barcelona Collaboratorium Centre for Genomic Regulation (CRG) Centre de Recerca Matemàtica | CRM-CERCA in AI/ML, Mathematical Biology, Modelling. Great opportunity for independence at an early career stage. Includes funding for a PhD student. Deadline 31Jan. pls RT crm-jobsboard.kenjo.io/Independent_Re…

Finally published. In this paper we showed that despite heterozygous exonuclease deficiency of pold1 has a minor effect on the germline and somatic mutation rate. Homozygous deficiency increase mutation rate by 2 orders of magnitude and causes cancer nature.com/articles/s4143…

Excited to finally have this preprinted: Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing by ⁦Pablo Baeza Centurion⁩ and many. ⁦Centre for Genomic Regulation (CRG)⁩ ⁦Wellcome Sanger Institute⁩ biorxiv.org/content/10.110…

New paper from our lab is now published. About #p53 inducible genomic stability regulator RNF144B, led by PhD student etna abad UPF Medicine and Life Sciences. Thanks to all coauthors, collab sara sdelci Donate Weghorn,funds CaixaResearch Asociación Española Contra el Cáncer Agencia Estatal de Investigación👇jeccr.biomedcentral.com/articles/10.11… #Aneuploidy

📣 Two ERC-funded positions are available in the lab! If you’re interested in exploring the mechanisms underlying mutation, we’d love to hear from you. ibe.upf-csic.es/work-with-us/j… RTs and shares would be greatly appreciated!

Very happy to announce our paper on mutational signatures caused by MMR knockouts. We find SBS57 is driven by alignment errors in MMR-deficient cells, experimentally confirm the MMR link with SBS1 & show differences between in vitro and in vivo MMR loss: tinyurl.com/ycyprxme

Very proud of Bobby Bentham and his excellent new tool…we’ve been working on this for a while, very much hope it’ll be useful.