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Excited to share that our work by Patrick Rodrigues and Tong Wu is published in Cell: RORγt+ DCs are required to induce oral tolerance. Their absence reduces pTregs and impairs oral tolerance to dietary antigens. Read more: authors.elsevier.com/sd/article/S00…

Super important work from our colleague and friend, Marco Colonna The Colonna Lab|| Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell cell.com/cell/fulltext/…

latest from our lab: ITACONATE MECHANISM SOLVED!! Tom Paulenda Tomas Paulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages: nature.com/articles/s4225… Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in

In this Insights piece, I discuss the recent study by Sun et al. Gardner Lab, which advances our understanding of tolerogenic RORγt⁺ APCs. I also briefly overview current knowledge and future directions in this rapidly growing field. Grateful to JEM for the opportunity.

Big shoutout to Brown’s group: IRF8-dependent TC are essential for inducing food-specific pTregs & establishing oral tolerance! In line with recent work from Mucida’s, Littman’s, Gardner’s, and our group highlighting the role of RORγt⁺ APC in this process.rb.gy/rej77q

As RORγt⁺ APC gain attention for their tolerogenic roles, Schraml’s group also highlights their inflammatory potential. Key questions remain: How are RORγt⁺ APC specified? Are eTAC and RORγt⁺ DC distinct or the same? What dictates tolerance vs. inflammation? Fast-moving field!

Find the referenced papers below: Brown: rb.gy/rej77q Mucida: rb.gy/1ulzqt Littman: rb.gy/9v8ke8 Gardner: shorturl.at/vTk7k Schraml: rb.gy/yhw499 Colonna: rb.gy/w50y70