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RecA mediated homology search finds segregated sister locus in minutes after a double stranded break biorxiv.org/cgi/content/sh… #bioRxiv

The second paper from my PhD is finally out in Nature Microbiology! TraDIS on IncC conjugation. Thanks to Minh-Duy Phan, Schembri Lab. Some really cool structural biology by Lou Zhenyao and Bostjan Kobe. nature.com/articles/s4156…

3 weeks to go -- waiting for your applications!

New reprint from our lab. An innovative antibacterial approach using conjugation to deliver CRISPR/Cas9 systems. Targeted-Antibacterial-Plasmids (TAPs) combining conjugation and CRISPR /Cas systems achieve strain-specific antibacterial activity biorxiv.org/content/10.110…

Erwan Gueguen I think this is a very nice study which highlights both the strength (programmability and efficiency of CRISPR-Cas to kill strains or cure plasmids & protection against transfer of targeted mobile elements) as well as the main current limitation: limited transfer efficiency.

What about DNA-binding proteins' diffusion before/after chromosome degradation in E. coli cells? Our new article is online: authors.elsevier.com/sd/article/S10…

The TacC lab has been awarded the Equipe FRM2021 funding for research on bacterial DNA transfer

The LAB coordinates the STARS-TAP project funded by the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR-HARISSA 2022-2025)

After reconsidering with the help of my trusted scientific community, I have decided to step down from this guest-editor duty. Thanks to all and sorry for the poor decision timing.

New BioRxiv pre-print from the TacC lab reporting the intracellular dynamics of plasmid transfer by conjugation in real-time. biorxiv.org/content/10.110…

New preprint from the Lab! Now we know ! The F pilus can serve as a conduit for the DNA during conjugation between distant cells biorxiv.org/content/10.110…

How RNAP keeps E.coli rolling with only a few rRNA "factories"? See our new NAR paper! Big thanks to Jun Fan (now PI at Chengdu) who led this in vivo single-mol work, and to all contributors, esp @HAFEZELSAYYED and Oliver Pambos! academic.oup.com/nar/article/do…

New paper! So pleased to see our Imaging + Deep-Learning way to rapidly detect antibiotic resistance out in Comm Biology rdcu.be/dq48G! Big thanks Alexander Zagajewski Piers Turner! Wonderful collab w/Nicole Stoesser OUH & Christoffer Nellaker funded by Oxford Martin School #AMR

New publication from the TacC Lab in collaboration with the Erhardt Lab. A long-awaited proof of DNA transfer via the extended conjugation pilus. pnas.org/doi/10.1073/pn…

A recent preprint also from Eugene Koonin discovered that the restriction of HGT by defense systems is species-specific and depends on various ecological and genetic factors biorxiv.org/content/10.110…

For those interested in "The Winding Journey of Conjugative Plasmids Towards a Novel Host Cell" authors.elsevier.com/sd/article/S13…

Just Brilliant! Congrats Nathan!