Daily Mundane for a #dermpath lover😊😂 Jacob Smalberger, M.D. Jonathan He Olaleke Folaranmi Lorand Kis Pepe Jiménez Heffernan @ArjunRamaiya1 Hansini Laharwani Tristan Rutland MBBS FRCPA IFCAP

This was a curbside consult from #dermpath. Patient has a history of mastectomy for breast cancer and is now presenting with a chest wall skin nodule. What is your diagnosis? - IHC: p63 @wusm_pathology WashU Medicine Pathology & Immunology Education #breastpath #PathTwitter #PathX

50M w/ longstanding UC, visible polypoid mass in sigmoid colon. HGD or no? #PathTwitter #PathX #GIPath

47 y/o F Circumscribed, unencapsulated mass of the deep R thigh +Ki67, Reticulin - S100, keratin H3K27me3 Dx? #pathagonia #softtissue #ortho #surgx #hemeonc #mskx #orthopedics #pathx

Lipoid subtype of urothelial carcinoma can truly mimic a well dif liposarc. Adding to the confusion is the frequent MDM2 amplification that can be seen in both. Key is to identify conventional UCa. Not uncommonly, the lipoid component loses keratin expression. #gupath

Ugh. Melanoma fooled me. Two initial immunostains (desmin and actin) were negative - I regrouped and sorted it out. Not the first time - won't be the last. Melanoma's always there to humble us. #UMiamiPath

Renal medullary carcinoma usually presents with metastasis. Located in the medullary region shows tubulopapillary, cords or solid sheets of cells w/ high nuclear grade and eosinophilic cytoplasm. Neutrophilic infiltration is characteristic. #gupath

65 year old man posterior auricular neck deep dermal nodule. easy peezy?#dermpath #PathTwitter #dermatology Etan Marks, DO @ArjunRamaiya1 Lorand Kis Olaleke Folaranmi Tristan Rutland MBBS FRCPA IFCAP Trish Stratus Marcelasaeblima. Allison Osmond MD MSc FRCPC Ahmed Alomari, MD Gonzalo De Toro

Cellular Angiofibroma (photo 1) Myofibroblastoma (photo 2) Spindle Cell Lipoma (photo 3) Molecularly, how are they similar? #pathagonia #molecular #breastpath #softtissuepath #softtissue #pathx #pathology Credit: UofMich Path Deck

BCOR IHC✅sensitive🚫specific for BCOR-altered Sarcoma Molecular for each BCOR fusion/ITD isn't available The IHC (+) trifecta of SATB2, cyclin D1, & BCOR* is specific and essential to diagnose BCOR-altered sarcoma *each (not all) + in other poorly diff tumors #BSTPath #PediPath

Invasive ductal carcinoma with osteoclast-like giant cells (Grossly “rusty” tumor)📘 📸 #pathology #pathtwitter #Breastpath #breastpathology

Happy Monday everyone! This is an incidental finding in a reduction mammoplasty. What is your diagnosis? #breastpath #PathTwitter WashU Medicine Pathology & Immunology WashU Medicine Pathology & Immunology Education

Adult female, reproductive age, omentum. #BSTpath #Gynpath #GIpath #Pathtwitter #Pathresidents

60s F 7.8cm subscapular (inferior tip) mass, with focal rib erosion. Subfascial, possible intramuscular. Dx/IHC? More images below. #PathTwitter #PathX #BSTpath

75 yo man w a nodule on the eyebrow. A perfect example of this entity! Answer ✅ youtu.be/4C7BDu6Ed-c?si… Amazing WSI digital slide: kikoxp.com/posts/3708. #Pathology #dermpath #dermatology #dermatologia #dermtwitter

Paraganglioma Cervical nodule Epithelioid (but CK-) cells with eosinophilic cytoplasm, ovoid and salt and pepper nuclei, arranged in a nested pattern. Neuroendocrine markers + S100 +: sustentacular cells #path #pathology

Excision of a mass from the parapharyngeal space reveals tumor cells arranged in an organoid (zelballen) pattern. What is the diagnosis? Answer: buff.ly/2hLDBy3 #PathArt #PathTwitter #MedTwitter

Case of Desmoid-Type Fibromatosis 〰️〰️🔬 ☑️ Long, sweeping infiltrative fascicles ☑️ Bland spindle cells and collagenous stroma ☑️ Associated with CTNNB1 and APC mutations #PathX #PathTwitter #breastpath

Distal rectal polyp - HPV-associated glandular neoplasms are rare and mimic tubulovillous adenomas. The mucin is peculiar and apical apoptotic bodies can be plentiful (arrow). Voltaggio L, et al. Mod Pathol. 2020 May;33(5):944-952. PMID: 31857682.

Middle-aged male. Peritoneal nodules. #PathX #PathTwitter #SurgPath