The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself: link.springer.com/10.1038/s41467…

Everything is ready for our #YP3 retreat in the Lake District, UK. Two days talking about #pyrenoids, #LLPS and carbon fixation … Physics of Life Biology at York Luke Mackinder Engineering and Physical Sciences Research Council Mark Leake

AlphaFold 3 is out! As expected expands coverage to small molecules and nucleic acids. And replaces the structure module with a diffusion-based one. Unfortunately no code or model weights--just a web server for a limited set of ligands: blog.google/technology/ai/…

Here is my biggest contribution to #science so far. A short series of memes inspired by #AlphaFold3 from Google DeepMind 1/9🧵

Very excited to share the preprint of a big chapter of my PhD, where I am corresponding & shared first author (together with Tanguy Chotel) about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas: Below in a 🧵: biorxiv.org/content/10.110…

cell.com/cell/fulltext/…

OK, our final -and biggest- Loeb give-away for the summer: 31 of them by the looks of it! Sophocles, Euripides, Cicero, Sallust, Suetonius, and the dirtiest poet of all, Martial in 3 vols. Draw 10pm Thurs BST: just RT and follow us before then! And vote below for 1 or 2 winners!

Excited to share our latest preprint! Biogenesis, engineering and function of membranes in the CO2-fixing pyrenoid biorxiv.org/content/10.110…

It's out in Cell!!! Super proud bug- and structural virologist moment; my paper about using CryoEM to discover, diagnose, characterize, and mitigate a nationwide agricultural pandemic is now published online 😄🐛🪲 cell.com/cell/fulltext/…

Very cool translational research using cryoEM

We have an opening at Bioscience @ NTU for a tenure track position in the Molecular and Cell biology of disease. We are very flexible about the study system, it could definitely be plants (or algae :) ) nature.com/naturecareers/…

Cell must be pissed

.MSU-DOE Plant Research Laboratory is conducting a search for an Assistant or Associate Professor in the area of the biology or biochemistry of photosynthetic organisms, interpreted broadly. We are looking for excellent researchers/scholars, who will enrich the department. buff.ly/47hpRLh

🚨 We’re hiring! 🚨 The School of Biological Sciences at Nanyang Technological University is looking for a TT Assistant Professor specializing in the Molecular and Cell Biology of Disease. Come join us as a colleague! Please help spread the word! 🙏 nature.com/naturecareers/…

cyanobacteria can have multiple distinct forms of rubisco! check out our new preprint to learn about the unusual carbon fixation machinery of an low O2 prochlorococcus and what we think it might mean for physiology and ecosystem biogeochem

I have a PhD scholarship available for a student to join my group @ntusg in the January 2025 intake. The student will work on a project related to the cellular biochemistry of the diatom pyrenoid. Here is our first paper on the topic: pnas.org/doi/abs/10.107…

A blueprint of the diatom pyrenoid reveals a Rubisco encapsulating protein Shell is critical for CO2 fixation. Is it essential for global NPP? Congrats to Onyou Nam,James Barrett,Caroline McKenzie,Jamie Blaza + great collab with Manon Demulder,Ben Engel.doi.org/10.1016/j.cell…

Congrats James Barrett & co! My fave story this year: delving into nature's different approaches to condensing Rubisco into a pyrenoid 🤩 Same mechanism, different execution - and it works in land plants!! Huge implications for crop engineering nature.com/articles/s4147…

Dramatic changes in mitochondrial subcellular location and morphology accompany activation of the CO2 concentrating mechanism | PNAS pnas.org/doi/10.1073/pn…

After 13 wonderful years in Singapore, my lab will move to the University of Virginia in January 2025. We are excited to continue exploring chromatin inside cell nuclei. Please get in touch if you're interested in joining!