Researchers study how nutrient stress leads to upregulation of a cancer stem cell marker, integrin αvβ3, which promotes metabolic plasticity in lung cancer cells. Nam et al. UC San Diego Health NINDS National Cancer Institute NIGMS (ORIP support through K01OD030513) pubmed.ncbi.nlm.nih.gov/38588407/

⌚️Researchers discover different sample collection times can lead to different conclusions in microbiome studies. Allaband et al., @NIAIDnews, NIH NHLBI, National Cancer Institute, NIDDK, NCATS, NIAAA News UCSD Biomed Sciences PhD Program (ORIP support through T32OD017863) pubmed.ncbi.nlm.nih.gov/38951660/

🐵Researchers conducted genetic sequencing on 1,845 rhesus macaques and identified potential new models of human neurodevelopmental and vision disorders. Wang et al., (ORIP support through P51OD011107, P51OD011106, P40OD012217, S10OD032189) nature.com/articles/s4146…

👀READ: “A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection.” Wahl et al., National Cancer Institute NIAID News NIDDK (ORIP support through P40OD010995) ncbi.nlm.nih.gov/pmc/articles/P…

The #ORIPResourceOfTheMonth is here! 🤩 Check out how the 𝐴𝑚𝑏𝑦𝑠𝑡𝑜𝑚𝑎 Genetic Stock Center (AGSC) supports biomedical research due to axolotl's remarkable ability to regenerate lost or damaged tissue! AGSC (ORIP support through P40OD019794) orip.nih.gov/division-compa…

🚨In this month’s #ResearchHighlight, check out how ORIP's supported small business Ramona Optics Inc. is overcoming challenges and limitations of current microscopes with the MCAM™ imaging technology. Ramona Learn more: orip.nih.gov/about-orip/res…

🔄Learn how researchers engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer. Smith et al., @NIAIDnews NIH NHLBI (ORIP support through U42OD027094, P51OD011107) pubmed.ncbi.nlm.nih.gov/38715362/

🧑‍🔬Recent study shows that 𝑖𝑛 𝑢𝑡𝑒𝑟𝑜 exposure to Zika virus due to maternal infection results in significantly decreased myelin formation around neurons. Tisoncik-Go et al., @NIAIDnews NEI (ORIP support through P51OD010425) nature.com/articles/s4146…

🧊❄️Join us for the virtual workshop on Cryopreservation and Other Preservation Approaches for Animal Models. This workshop will be held as a series of sessions from Sept. 6, 2024, through May 2025. NIGMS, NICHD News. Register now for the workshop at: scgcorp.com/Cryopreservati…

New release from ORIP and NIH OAR. Read the Nonhuman Primate Evaluation & Analysis Report to learn about the demand for & supply of nonhuman primates in the U.S. The study also forecasts future needs & will empower researchers in planning for the future. orip.nih.gov/about-orip/res…

READ "Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates." Zhang et al., Nat Commun. (ORIP support: P51OD011133, P51OD011104, U42OD010442) ncbi.nlm.nih.gov/pmc/articles/P…

🐒Researchers demonstrate successful genome editing in the lungs of young rhesus monkeys using AAV5. Liang et al., RNA Therapeutics Institute Koch Institute at MIT NIH NHLBI, National Cancer Institute, NIGMS (ORIP support through U42OD027094, P51OD011107, S10RR025063 & S10OD028713) pubmed.ncbi.nlm.nih.gov/38767512/

⚛️⚙️Scientists regulate naturally inspired “synpoptosis” circuits that produce engineered executioner proteins and mammalian cell death. Xia et al., HHMI UCLA-Caltech MSTP (ORIP support through F30OD036190) #sciencetwitter ncbi.nlm.nih.gov/pmc/articles/P…

🧪READ: "Stable HIV decoy receptor expression after in vivo HSC transduction in mice and NHPs: Safety and efficacy in protection from SHIV." Li et al., Mol Ther., 2023 NIH NHLBI (ORIP support through P51OD010425) ncbi.nlm.nih.gov/pmc/articles/P…

A thank you for your thank you😊The scholars participating in the K-StateVetMed Veterinary Research Scholars Program this summer expressed their appreciation for the support provided by #ORIP. We hope to continue encouraging veterinarians to pursue careers in biomedical research.

READ: “Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies” Skeate et al., @NIAIDnews, National Cancer Institute, NIH NHLBI (ORIP support through F30OD030021, U24OD026641) pubmed.ncbi.nlm.nih.gov/38627969/

🐭READ: “Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner” Karagianni et al., Boston University Center for Musculoskeletal Research (ORIP support through K01OD025290) #sciencetwitter pubmed.ncbi.nlm.nih.gov/38635757/

CRISPR-Cas technology has transformed our ability to introduce targeted modifications allowing animal models like pigs to model human diseases thus, is critical to ID off-targeting modifications in their genomes. Agricultural Research Service Mizzou CAFNR (ORIP support-R01OD035561) pubmed.ncbi.nlm.nih.gov/38770737/

Tomorrow🗓️Session I of the Cryopreservation & Other Preservation Approaches for Animal Models Workshop is taking place from 10am-4pm EDT. The session will feature talks on invertebrate models. NIGMS NICHD News Genetics Society of America Society for Cryobiology Register today: scgcorp.com/Cryopreservati…

Scientists gain important insights through mechanical and morphometric approaches to body mass estimation in rhesus macaques: using skeletal features for accuracy. Turcotte et al., Caribbean Primate Research Center CSHO @ NYU NYCEP (ORIP support through P40OD012217) pubmed.ncbi.nlm.nih.gov/38445298/