Tuning immunity through tissue mechanotransduction dlvr.it/SWkc3B

Congratulations to our PI Meenal Datta on being awarded the Berthiaume Institute for Precision Health grant to support the work on #drugdiscovery for #glioblastoma!

Check out our TIME Lab's new Perspective in Frontiers in Oncology where we explore the potential linkages between tumor mechanics and cancer metabolism in brain metastasis. Great job, Killian and Alice! #force4good frontiersin.org/articles/10.33…

Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues nature.com/articles/s4155…

Check out this Spotlight in Immuno-Oncology Insights where Prof. Meenal Datta Meenal Datta discusses different hypotheses and approaches that are at the core of our lab's research. insights.bio/immuno-oncolog…

New #braincancer research from Rony Chanoch-Myers 🎗️ Mario Suva & co Weizmann Institute which combines multiple #Glioblastoma datasets to define a core mesenchymal program & highlight 3 main MES states with distinct functional, genetic & environmental associations bit.ly/3dyMfrT

I was thrilled to be invited to speak about preclinical biomarker development from TIME Lab's engineering perspective at this year's 4th Macrophage-directed Therapies Summit! #NDengineering #AME #NDTIMELab #Force4good

Thanks to NAVBO for the invitation to speak about vascular immune-related adverse events during glioblastoma immunotherapy! #IVBM2022 #glioblastoma #irAEs

We finally unwrapped our shiny new 10x Genomics Chromium iX and it’s looking good in its new home at University of Notre Dame GBCF. Looking forward to many amazing discoveries with this instrument!

Had a great time at the inaugural TIME Lab dinner. I'm fortunate to have such a stellar group of students and fellows in the lab. Here's to another great year of research and fun together!

Congratulations to our undergraduate Bianca Batista who was offered the opportunity to attend the Women in Engineering 2022 conference in Houston, Texas – the world's largest conference for women in engineering and technology. We are proud of you, Bianca!

Join us for Teatime with Faculty featuring Meenal Datta who will talk about her career path in #STEM

Check out our lab's (TIME Lab) latest publication in Cells on the role of tumor mechanical stresses in immune evasion and immunotherapy resistance. Congrats to my Notre Dame Bioengineering/Notre Dame AME postdocs and students for a job well done! #force4good mdpi.com/2073-4409/11/2…

‘Tis the season for parties! In addition to the Notre Dame AME and Notre Dame Engineering events, we also held our inaugural TIME Lab holiday celebration and Secret Santa gift exchange.

Happy Holidays from the TIME Lab!

Our latest publication is out! Losartan reduces ICB-induced edema and improves survival in glioblastoma mouse models. Amazing teamwork! Meenal Datta Mario Suva MassGeneral News Mass General MDs Mass General Cancer Center @MGH_RI pnas.org/doi/10.1073/pn…

New study led by Prof. Meenal Datta University of Notre Dame Notre Dame AME Notre Dame Bioengineering shows how blood pressure drug boosts effectiveness of immunotherapy for combatting aggressive brain tumors. engineering.nd.edu/news/new-study…

Glioblastoma, a fast-growing and aggressive brain tumor, has so far resisted all therapies, including immunotherapy. A new study shows a widely prescribed blood pressure drug boosts the effectiveness of immunotherapy and reduces deadly side effect: go.nd.edu/bf869c

We are excited to see our our review paper on physics and immunity of peritumor online in Trends in Cancer (free download of pdf) authors.elsevier.com/a/1h1a98Z12yTu…

Make sure to visit the poster by Notre Dame AME and Notre Dame Bioengineering grad student Alice Burchett, focusing on #myeloidmechanics