🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Thrilled to share that I'll be starting a tenure-track assistant professor position at the Department of Genetics, Washington University in St. Louis, in January 2025! WashU Medicine Genetics I am recruiting lab members at all levels. For more details, visit our lab website or check flyer

Our paper is out today !!! link.springer.com/article/10.118… Rutgers CABM Nadav Ahituv Nir Yosef Taka Inoue @TalAshuach

Another beautiful story by Ari Daniel (ari daniel) NPR on the Belize bat-a-thon and our work on how fruit eating bats can eat so much sugar and not get diabetes. Amazing work by @GreatWeiShark and Mai Nobuhara! npr.org/sections/goats…

Four last days to register! Symposium on 9/9. We have a great lineup of speakers, plenty of time to network and registration is free. genotech.ucsf.edu/home

Excited to share the white paper for the IGVF Consortium, supported by National Human Genome Research Institute Deciphering the impact of genomic variation on function rdcu.be/dSZdm

We are recruiting two computational biologists/bioinformaticians with ML expertise and a focus on genomics, variant effects and gene regulatory sequences in staff scientist and postdoc roles in Lübeck, Germany. Please find details here: kircherlab.github.io/contact.html

An experimental census of retrons, now published in Nature Biotechnology. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. nature.com/articles/s4158…

Thank you to Kathy Giacomini, Christof Fellmann, David Schaffer, Francine Gregoire, Kyle Cromer, Emil Kakkis, Andrew Carroll, David Kelley, Danny Wells, Tony Capra, Christina Fan, Andrew Farmer, Wenjun Ouyang, and Yin Shen for their outstanding 2024 IHG Symposium talks!

Our paper describing a scalable method for Multiplex, single cell CRISPRa screening for cell-type specific regulatory elements is now published! rdcu.be/dUnoq nature.com/articles/s4146…

It was a lot of fun doing this! Thanks so much Patrick Short for hosting me!

Incredibly proud to share that I recently joined UCSF Bioengineering & Therapeutic Sciences UC San Francisco as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳

Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! biorxiv.org/content/10.110…

Beautiful work by Karissa Hansen and Elphege Nora Lab at UCSF on the role of cohesin in enhancer-promoter interactions. Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function biorxiv.org/content/10.110…

Thinking about a PhD using computational power to answer pressing problems in biology and health? UC San Francisco Biological and Medical Informatics PhD program is recruiting for Fall 2025! Join our info session next Monday Oct 21: bmi.ucsf.edu/admissions.

Very cool work by Yin Shen showing how allelic compensation can be used as a regulatory compensation mechanism. biorxiv.org/content/10.110…

1/🧵Excited to re-introduce Memento in (cell.com/cell/fulltext/…), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇

Updated VISTA Enhancer Browser, 7 years in the making, out in Nucleic Acids Res! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. enhancer.lbl.gov #enhancers #embryos doi.org/10.1093/nar/gk…