nature.com/articles/s4158… (1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in nature!

Real-time visualization of reconstituted transcription reveals RNA polymerase II activation mechanisms at single promoters biorxiv.org/cgi/content/sh… #biorxiv_biochem

A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses biorxiv.org/cgi/content/sh… #biorxiv_pathol

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development biorxiv.org/content/10.110… #biorxiv_devbio

There is a new platform, Sci-Net (sci-net.xyz) where researchers can help each other by providing paywalled papers. The platform builds upon Sci-Hub meme token $scihub to reward active members.

What is the role of Med23 in brain development and ADHD pathophysiology? Learn about the consequences of Med23 knockout and how methylphenidate may ameliorate the resulting ADHD-like behaviors nature.com/articles/s4138…

nature.com/articles/s4146…

The first #cryoEM structure of a Mediator complex subunit in complex with a transactivation domain nature.com/articles/s4146…

MED15 in elongation 🤔 nature.com/articles/s4146…

We discussed how perturbing the Mediator Complex, a key gene expression regulator, reshaped cellular phenotypes. Some perturbations induced autonomous dedifferentiation, while others led to drug-resistant states. Interestingly, their effects aligned with the complex’s structure!

Online Now: Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors dlvr.it/TL2Qrq

Structural insights into human Pol III transcription initiation in action by yanhui #cryoem nature.com/articles/s4158…

MED13L Pathogenic Missense Variants Impair Protein Stability and Interaction, Underlying Diverse Clinical Outcomes cell.com/hgg-advances/f…

Roger, Roger..... sciencedirect.com/science/articl…

The Mediator complex subunit Med19 extends healthy lifespan in Drosophila by preventing cellular and organismal frailty biorxiv.org/content/10.110… #biorxiv_cellbio

Demonstration of the crucial role of MED14 in fetal #organogenesis and elucidation of the mechanistic details underlying a potential link between #VACTERLAssociation and the Mediator complex. #DiseaseModel #OpenAccess: sciencedirect.com/science/articl…

It was a pleasure to present CSHL Meetings Mechanisms of Eukaryotic Transcription conference. Watch my summary of how gene expression can be stopped using the link below. Thanks to the audiovisual team at Cold Spring Harbor Laboratory for recording. lnkd.in/e5zxs24M

Inside @JbiolChem: New research sheds light on the fundamental mechanism of gene regulation by the Mediator complex. ➡️Read "N-terminal half of MED14 is critical for Mediator-RNA polymerase II interaction and the resulting transcription" here: jbc.org/article/S0021-….

A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence dlvr.it/TPB1Mt