Matthew Todd
@mattoddchem
Chair of Drug Discovery at @UCL. Founder, #openscience drug discovery consortia @O_S_M @MycetOS @OSantibiotics. Head, Open Chemistry Networks @thesgconline
ID: 21448858
https://todd-lers.github.io/about/ 21-02-2009 00:07:07
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Well done Yinuo Wang! #openscience #malaria #DrugDiscovery
Several #openscience projects in the lab are nicely poised for community inputs. Here's a peach. One of the Structural Genomics Consortium (SGC) Open Chemistry Networks needs some simple ureas. You make, we test. Protocols available. github.com/StructuralGeno… Target 2035 UCL Faculty of Life Sciences
An #openscience project needing community help from computational modellers. WDR91 for host-directed antivirals. We've binders + xstal structure. We need to understand the data, particularly the matched pairs. github.com/StructuralGeno… Structural Genomics Consortium (SGC) Target 2035 UCL Faculty of Life Sciences
Fragments and #openscience ftw! We've 18 frags bound at the interface of SARS-CoV-2 Nsp10 and Nsp14, and now we need to grow/merge/link. Details at github.com/StructuralGeno… Live and online at Fragalysis fragalysis.diamond.ac.uk/viewer/react/p… We can buy/make/measure. Structural Genomics Consortium (SGC) #antiviral
Yesterday's board dinner of Structural Genomics Consortium (SGC) at University of Toronto Faculty Club with aled edwards Levon Matthieu Schapira Ryan Merkley 🍁 Rachel Harding Cheryl Arrowsmith (& others not on X..). Such a fun group of talented researchers who advocate, and *do*, #openscience.
John Moult kicking off the CACHE Challenge Symposium in Toronto, describing the lessons learned from the CASP protein structure prediction competition Structural Genomics Consortium (SGC)
Love #orgchem? Love palladium catalysis? Love the Miyaura borylation? We do, but there's one we can't get working. We need it to enable high value compounds for #malaria in Open Source Malaria. See github.com/OpenSourceMala… for more. #openscience Yinuo Wang Medicines for Malaria Venture (MMV) Structural Genomics Consortium (SGC)
Deeply fun to welcome students from Whitgift School to UCL School of Pharmacy UCL Faculty of Life Sciences to analyse samples of a molecule they made for the #openscience drug discovery project Open Source Mycetoma We NMR'd, we mass specced, we figured it out. ucl.ac.uk/pharmacy/news/… Research in Schools
Interested in synthesis and synthesis prediction? Steve Marsden and I have a PhD studentship that is collaborative with Exscientia. Enhanced stipend. Open to UK students (and, in competition, to international applicants) phd.leeds.ac.uk/project/1706-d…
A combination of biochemical, structural, and modeling studies identifies OSM-S-106 as an exemplar of a new chemical class of species-specific reaction hijacking inhibitors. Matthew Todd #malaria #AntimalariaResearch #DrugDiscovery Read more: nature.com/articles/s4146…
Taking #openscience contributions to the next level. Whitgift School has provided their talented students, who have successfully made molecules for Open Source Mycetoma, with their own cool, branded labcoats. I have to get me one of those. Drugs for Neglected Diseases initiative #mycetoma #NTDs
Are you a computational chemist who loves #orgchem mechanisms? We could use a hand in this #openscience project relevant to new #antiviral molecules. Which mechanism is expected to operate in solution? More details at github.com/StructuralGeno… Rahman S Z Saleem Structural Genomics Consortium (SGC)
Weird wardrobe reversal with aled edwards at local UCL School of Pharmacy pub Skinners Arms Structural Genomics Consortium (SGC)
Perhaps surprisingly, we had a talk today from NASA in UCL School of Pharmacy providing, finally, a chance to wear my old NASA Voyager T.
Cycling in to UCL School of Pharmacy again, first time since COVID. Things that have changed: 1) Lime bikes, flocking like pigeons. 2) 50% of cyclists have ear buds in. If you don't do it in lab, don't do it on the road, people.
