Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365) 👉29,139 locus-trait pairs 👉2,624 non-overlapping loci across the genome 👉associated with 6 traits each (median) 👉colocalization across traits for 72% of loci [1/3]

🔗link to preprint: medrxiv.org/content/10.110… 📊summ stats: platlas.cels.anl.gov/downloads 🌐browsable results: platlas.cels.anl.gov [3/3]

Exciting developments in colorectal cancer treatment! Learn about ongoing clinical trials evaluating immune checkpoint inhibitor therapy for various stages of colorectal cancer with Andrea Cercek, Jenna Sinopoli, and our partner PeerView: bit.ly/3WDnnD3

At the AACR Conference 2025 in Chicago. Being Reviewer 2 for the grant writing workshop as part of the Professional Advancement Series. #AACR2025 #AACR #CancerResearch #AACR25

Exciting reads on genetics, omics, & precision medicine this week🧵 1⃣A tissue-specific atlas of protein-protein associations 2⃣A single-cell spatial transcriptomic map of human atherosclerosis 3⃣A primer on precision nutrition 4⃣Deep lipoprotein profiling for cardiovascular

GXwasR: A Toolkit for Investigating Sex-Differentiated Genetic Effects on Complex Traits medrxiv.org/cgi/content/sh… #medRxiv

A lesser-discussed use of polygenic risk scores (PRS): enriching clinical trial populations with high-risk individuals to boost event rates and thus reducing sample size, time, and cost🧬 This was tested in emulated trial settings👇[1/7]

Predicting gene expression from DNA sequence using deep learning models.#GeneExpressionPrediction #GenomeSequences #DeepLearning Nature Reviews Genetics nature.com/articles/s4157…

A neat example of how tissue pQTLs & eQTLs can complement the interpretation of GWAS data for complex traits. The study links GWAS loci for kidney function & hypertension to gene & protein expression in kidney tissue. It's also a great resource for further downstream analyses.

🔗link to the study: nature.com/articles/s4159… 📊summary stats: susztaklab.com/pl/pQTL

Also, an excellent editorial on our work by Michael D. Shapiro

🔗link to the caQTL preprint: medrxiv.org/content/10.110… 🔗link to the previous single-cell eQTL preprint from TenK10K: medrxiv.org/content/10.110… 📊summ stats to become available with publication

🔗link to the paper: nature.com/articles/s4158… 🔓open-access preprint version: medrxiv.org/content/10.110… 📊access to GWAS summary statistics: pan.ukbb.broadinstitute.org

In 2025, 21,000 adults in their 40s or younger will be diagnosed with colorectal cancer. Mariana is just 26 years old with stage IV metastatic colon cancer. This #WorldmCRCDay, Mariana is reminding people that if you're experiencing anything abnormal at any age, it's imperative

Study Links Genetic Variation to Chemo-Related Liver Damage in Pts W/ CRC Liver Mets Patrick Starlinger_TELL International Mayo Clinic Comprehensive Cancer Center #crcsm https://www.onclive/com/view/new-study-links-genetic-variation-to-chemotherapy-related-liver-damage-in-patients-with-colorectal-cancer-liver-metastases

New online! Clinical use of polygenic risk scores: current status, barriers and future directions bit.ly/48oQiRD

Polygenic scores (PGS) have been developed for years, yet few are close to clinical use. Prostate cancer PGS is among the most advanced, with trials now evaluating clinical utility. A nice weekend read on the path to translation, with implications for other disease areas.

🔗link to the review 🔓: rdcu.be/eKOkh

European ancestry predominance used to be a bottleneck in population genetics. More initiatives focus on other ancestries now. The Emirati Genome Program includes 👉whole genome sequencing in N=504,000 👉longitudinal EHRs for 426,382 of them 👉reconstructed pedigrees

Data access according to their previous preprint (medrxiv.org/content/10.110…): Data access for this study is provided through the Emirati Reference Genome Program (EGP) website hosted via the Department of Health (DoH). Researchers can request data access by completing the Data