Great #GUTAbstract by Mantovani et al entitled "Association between primary hypothyroidism and metabolic dysfunction-associated steatotic liver disease: an updated meta-analysis" via bit.ly/4dotUao Paper: bit.ly/46qHoA0 Alessandro Mantovani Luca Valenti #MASLD

More on the use of negative controls as falsification strategies in Mendelian randomization (MR) studies by Zoe Reed et al onlinelibrary.wiley.com/doi/10.1002/ge… Negative controls are heavily under-utilized in MR to date; incorporation should become routine

The 5 different patterns of brain aging from ~50,000 individuals, with their relationship to lifestyle, genetics and outcomes, derived from MRI and #AI. nature.com/articles/s4159… Nature Medicine Christos Davatzikos and colleagues

cardiab.biomedcentral.com/articles/10.11… #T2DM #hepcidin #ferritin #mortality

MetALD is surely the new intriguing kid on the SLD block NHANES, n=105 MetALD vs MASLD: 🔽 insulin resistance 🔼TGs & BP 🔼Steatohepatitis but not worse LSM 📰 Liver International 🔗onlinelibrary.wiley.com/doi/10.1111/li… Why? Likely socioeconomy, as shown by Helle Lindholm Schnefeld #EASLcongress #LiverTwitter

New from us: Socioeconomic factors and association with liver outcomes in >14,000 patients with #MASLD. onlinelibrary.wiley.com/doi/10.1111/li… Thanks to 1st au Patrik Nasr and nice collaboration with Jeffrey V. Lazarus et al. Karolinska Institutet #livertwitter Out now in Liver International

Evidence from omics that aging is not a gradual, linear process. The new study, highlighted here, only assessed people up to age 75 among 108 participants with short term follow-up (1.7 yrs). A previous large study (N>4,200, up to age 95) found a 3rd peak at age 80.

End of the antibiotic prophylaxis era for #cirrhosis

📣 The final version of our article is out in ⁦JHEP Reports⁩! Take a look 👀 and discover that loss of #estrogen due to #menopause causes a masculinization of the #female #liver mediated by #ERa and promotes #MASLD! #DrJekyllAndMrHyde #LiverTwitter kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

📣 Our review on “Sex‐specific effects of PNPLA3 I148M” is out in ⁦Liver International⁩ Kudos to Alessandro Cherubini and Chiara Rosso. Good team work, my friends 😊 #LiverTwitter #SexDifferences #PNPLA3 #MASLD onlinelibrary.wiley.com/doi/full/10.11…

In today’s #readoftheweek📚, the authors’ findings highlight the role of liver biopsy in elucidating the underlying pathology and aiding in the diagnosis of patients with persistent and unexplained GGT elevation. Read here this JHEP Reports article: jhep-reports.eu/article/S2589-… 🙏

Who cares…? science.org/doi/10.1126/sc…

Liver transplantation plus chemotherapy versus chemotherapy alone in patients with permanently unresectable colorectal liver metastases (TransMet): results from a multicentre, open-label, prospective, randomised controlled trial - The Lancet thelancet.com/journals/lance…

Excited to introduce the #GENIALProject – where AI meets precision medicine! We're exploring AI-driven innovations to advance personalized healthcare and transform the future of patients with alcohol-related hepatocellular carcinoma (ALD-HCC)🌐🔬 #AI #Healthcare #Innovation

New insights into liver fibrosis in Liver International! SHG/TPEF microscopy with #AI offers precise assessment of #fibrosis in MASH F3 patients, revealing changes even when standard scoring shows 'no change.' #livertwitter David Kleiner bit.ly/3Tyu8nG

💥Hepatology Snapshot Estrogen receptor alpha in the female liver: Dr. Jekyll and Mr. Hyde Find it here👉journal-of-hepatology.eu/article/S0168-… Sara Della Torre Luca Valenti #LiverTwitter

Mancano due giorni alla Conferenza monotematica AISF “Hepatic Cirrhosis: Twenty Years Later”, che si tiene il 27-28 settembre presso l’Università degli Studi di Salerno. Al seguente link info e programma: buff.ly/4d8KsT1

#RICERCA "World's Top 2% Scientists": #PoliclinicoMi brilla con 83 #ricercatori ai vertici mondiali Leggi la news e scopri i nomi dei nostri #scienziati presenti nella classifica ▶️ bit.ly/3XYTLAI

My piece Science Magazine today What happens when you can assay over 10,000 proteins in the blood, in tens of thousands of people with years of follow-up, and use #AI analytics? An exciting, but largely unrecognized new frontier in medicine; open-access science.org/doi/10.1126/sc…

The classical taxonomy of the basic unit of life is a deeply challenged since the advent of single cell sequencing. A smart discussion. What is a cell type, really? The quest to categorize life’s myriad forms nature.com/articles/d4158…