Such a fantastic read from Daniel Fisch, Jonathan Kagan, and co. The cell biology of endogenous proteins is so important and understudied. Congrats on this excellent study!

#Necroptosis is the primary type of cell death affecting human lung cells at the start of #SARSCoV2 infection, according to a new study. scim.ag/7Er

SARS-CoV-2–infected cells undergo necroptosis while apoptosis/pyroptosis occur in uninfected bystander cells resulting in extensive cellular injury Science Immunology Kat Barnett Kaixin Liang Ting Lab science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

Big thank you to Lok-Yin Roy Wong and Stanley Perlman for the fantastic focus article on our Science Immunology manuscript out today! science.org/doi/10.1126/sc…

Want to know which death pathway dominates COVID-19 infections? Look no further than the stellar study by Barnett and Liang, from Jenny Ting’s lab. ZBP1-dependent necroptosis is key. Kudos on a fantastic study. science.org/doi/10.1126/sc… Kaixin Liang Kat Barnett Ting Lab

#NoTimeToDie! Ting Lab Kaixin Liang Kat Barnett &co show Science Immunology that #SARSCoV2 induces necroptosis, apoptosis & GSDME pyroptosis in human airway epithelial cells! Infected cells die by #necroptosis via Z-RNA recognition by ZBP1 (up in Delta) science.org/doi/10.1126/sc…

Lung cells directly infected with #SARSCoV2 undergo #necroptosis cell death while bystander cells separately undergo #apoptosis. Ting Lab Read more in Science #Immunology: scim.ag/7GG

Researchers in the lab of Jenny Ting, PhD, have mapped out exactly how human airway cells die after being infected by SARS-CoV-2. 🔬 The findings suggest that cell death may directly influence the progression of #COVID19. Science Immunology news.unchealthcare.org/2024/07/study-…

Really excited to share a short tweetorial of some of my work as a grad student in the Igor Brodsky lab Penn Vet, now in press at Science Advances! 🧵👇science.org/doi/10.1126/sc…

In vivo evidence that failed pathogens, resulting from infidelities in infection strategies, are the drivers of innate immunity. Krause and Cepko discovered that in the brain, non-productively infected cells are the source of interferon. pnas.org/doi/epub/10.10…

#CoagulationAndImmunity! Ryu, Katerina Akassoglou &co show nature that the #SARSCoV2 Spike binds & activates #fibrin, driving type I interferon signaling, macrophage activation, NK cell inhibition, & neuroinflammation, independently of infection! #LongCOVID nature.com/articles/s4158…

Evidence continues to emerge that inflammasomes operate in living cells. Superb study by Latz et al showing gut bacteria metabolites in NLRP3 activation in live macrophages. Kudos to the authors. cell.com/cell-reports/f…

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper Cell with Achille Broggi! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5