Online Now: Transcription activation is enhanced by multivalent interactions independent of phase separation dlvr.it/SQ3L3w

Happy that our study on #TF binding properties is out. We found #droplets have a neutral/negative effect on transcription but #multivalentinteractions and long #residencetime enhance it. Thanks @LukasFrank91 Karsten Rippe and everyone involved for the great time working together!

So excited to finally have our new spatial omics method, Light-Seq, which directly integrates imaging with NGS, out in Nature Methods! And Josie Kishi has already prepared an awesome thread explaining how it works. nature.com/articles/s4159…

Promoter activation by TFs involves multiple energy-dependent steps. We discuss recent studies on how this is related to binding kinetics, proofreading and nuclear sub-compartments. It was fun working and reading up on this topic with Karsten Rippe during my time in his lab.

Mammary micro vessels are sensitive to menstrual cycle sex hormones, this fantastic work led by @CarmenMoccia0 from HaaseLab is online! #perfusablevessels #hormones #vascularremodeling #organsonchip biorxiv.org/content/10.110…