See how CRLs forge ubiquitin chains on substrates - and degrader-recruited neo-substrate - at high-res! Millisecond polyubiquitylation! #cryoEM #TPD NatureStructMolBiol Max Planck Institute of Biochemistry (MPIB) UNLV College of Sciences 👉shorturl.at/eFS68 Related exciting work from Alessio Ciulli shorturl.at/hNSU5

See cullin-RING E3s forge #ubiquitin chains on substrates and degrader-recruited neo-substrate at high-res! Millisecond polyubiquitylation! #cryoEM #TPD NatureStructMolBiol ❕nature.com/articles/s4159… Also, ... (1/2)

Now out in Molecular Cell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM Max Planck Institute of Biochemistry (MPIB) UNLV College of Sciences St. Jude Research @DanielS20127197 rajan prabu (1/2)

Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here: authors.elsevier.com/sd/article/S10…

You are a highly talented researcher? The departments of Brenda Schulman and Matthias Mann are looking for you! Check out the #job offer: ❕apply as soon as possible ❕mpg.de/21767203/phd-s… #hiring #JobAlert Matthias Mann Lab #ubiquitin #E3ligase #UPS #massspec #structural_biology

🚨Excited to share that our manuscript is now published in NatureStructMolBiol. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome. Max Planck Institute of Biochemistry (MPIB) @HarvardCellBio Aligning Science Across Parkinson’s nature.com/articles/s4159…

Synple Chem (Synple Chem) and Enamine partner to jointly develop a new chemical space by fueling the world’s largest collection of building blocks provided by Enamine to Synple Chem’s reaction outcome prediction tools. Read full Press Release: bit.ly/3JGtQ9c

Would you like a data set of 40,000 reactions for evaluating your reactivity prediction models? We made it, so you don’t have to. 1/10

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in Molecular Cell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, D.Sherpa, Arno Alpi Schulman lab Max Planck Institute of Biochemistry (MPIB)

Check out the study on the first identified human protein whose stability is regulated via Pro/N-degron and CTLH E3 ligase

Delighted to see our paper out in Nature Communications! We uncovered that alkylamine-tethered molecules recruit FBXO22 for TPD, making it an exciting addition to the TPD toolbox. nature.com/articles/s4146…

New preprint! 🧬🖥️ With the Johannes Walter, we created a predictome of nucleosome acidic patch binders using AlphaFold. Our approach identified both known and novel acidic patch interactors, opening new avenues for chromatin research. Check it out: biorxiv.org/content/10.110… (1/3)

Published today, our fantastic collaboration with Lindsey James group, Brian Raught, and Licht Lab. Thanks to the talented David Nie and John Tabor! nature.com/articles/s4158…

AI is accelerating structural biology! 🧬📷 Read my interview in Harvard Medicine News to explore the future of AI-powered research: hms.harvard.edu/news/how-machi…

Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HDR donor templates. Check out our paper in Nature Biotechnology for the story & ways to improve HDR. nature.com/articles/s4158… With Erman KARASU & John Maciejowski

Congratulations to graduate students @AMohamed_98 from our group and Peter Wang from the Bartel lab on determining the structure of human AGO2 in the slicing conformation. This was a challenging project with many exciting results. Read our preprint to learn more!

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert tinyurl.com/setd2

Our collaborative AGO2 work with the Bartel lab is published! @AMohamed_98 and Peter Wang used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing

Excited about mechanistic biology and processes in the cell's nucleus? Join our lab as a post-doctoral researcher! We have a state-of-the-art cryo-EM facility at HMS, a brand-new lab space, and a vibrant community at HMS! DM/email me or check farnunglab.com