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Happy to share our latest work in which we present a novel method to study leukocyte recruitment to human atherosclerotic plaques. We found that CD8+ T cells recruitment to human plaques is mediated by ACKR1+ IP neovessels! ahajournals.org/doi/10.1161/CI…

Why are ACKR1+ intraplaque neovessels key in atherosclerosis? These venular vessels express CXCL12 that attracts CD8+ T cells via CXCR4 in the plaque This may unlock new cardiovascular therapy #Atherosclerosis #Chemokines Read our study here 👇👇👇 ahajournals.org/doi/10.1161/CI…

T cells, especially CD8, are recognized to be the main hematopoietic cells in human atherosclerotic plaques. How are they recruited? We developed a 3D tissue culture model and found that intraplaque ACKR1+ vessels secrete CXCL12 and recruits CD8 cells. ahajournals.org/doi/10.1161/CI…

Very excited to share our latest discoveries revealing the crucial role of the merhyltransferase Ezh2 in T cells during #atherosclerosis 🧬 Doro Atzler Esther Lutgens IPEK CRC1123: Mechanisms of Atherosclerosis DZHK Germany Universität München Now online Circulation ahajournals.org/doi/full/10.11…

Congratulations to Harini Balasubramanian on her Master’s degree - well done! I am proud of you and the work you've done in the lab👩‍🔬 Looking forward to exciting future work together! IPEK

CXCL12-CXCR4 axis drives CD8+ T cell plaque infiltration and may play a role in human atherosclerosis Laura Parma ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE IPEK @LarsMaeg Marie Depuydt ahajournals.org/doi/full/10.11…

Played a minor part but that’s us CRC1123: Mechanisms of Atherosclerosis

📢Looking forward to our next joint CRC/IRTG 1123 🧑‍🏫Seminar Series next week 🗓️DFG public | @[email protected] @LMU_Uniklinikum 🗣️ Slava Epelman Slava Epelman UHN Research Peter Munk Cardiac Centre Ted Rogers Centre for Heart Research University of Toronto 📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages ipek-research.com/news-reports/e…

📢Looking forward to our next joint CRC/IRTG 1123 🧑‍🏫Seminar Series this week 🗓️DFG public | @[email protected] Universität München 🗣️ Slava Epelman Slava Epelman UHN Research Peter Munk Cardiac Centre Ted Rogers Centre for Heart Research University of Toronto 📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages ipek-research.com/news-reports/e…

📢#TODAY Looking forward to our CRC/IRTG 1123 🧑‍🏫Seminar Series DFG public | @[email protected] Universität München 🗣️ Slava Epelman Slava Epelman UHN Research Peter Munk Cardiac Centre Ted Rogers Centre for Heart Research University of Toronto 📌 Enhancing engineered 🧫heart tissues with macrophages ipek-research.com/news-reports/e…

Great emotional week with conferences, defended thesis and meeting old colleagues. Congratulate Dr. George Shakir on his new achievement. linkedin.com/posts/raquel-g…

📢Looking forward to our next Graduate CRC1123 👩‍🏫 Lecture Series next week by🗣️Zhifen Chen TU München on Risk 🚨and Resilience Mechanisms for Coronary Artery Disease 🫀🩺 in #Obesity 📏⚖️ ipek-research.com/news-reports/e… DFG public | @[email protected]

#TODAY 🗓️5pm CRC1123 Graduate 🎓Lecture 🧑‍🏫by Leo Nicolai on #Platelets in acute and chronic #inflammation ➡️ ipek-research.com/news-reports/e… DFG public | @[email protected] Sabine_Steffens

📢Registration is open for the International 🗺️#Atherosclerosis Symposium in Munich 🥨, Oct 21–22, 2025! 🧬 Hosted by DFG public | @[email protected] CRC 1123. Join top experts🧑‍🔬👩‍🔬 for talks, posters & networking! Abstract deadline: July 31. ➡️Details & sign-up: mias2025.de #Science

A preclinical study uncovers a metabolic pathway that offers a target in neuropathic pain, scientists discover how chemokines can support red blood cell production in mice, and more this week in #ScienceSignaling. scim.ag/3HEv8no

Not all chemokine signaling is about cell migration! In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation. 🔗 science.org/doi/10.1126/sc… #chemokine #CXCR4

In a new study, researchers find that the chemokine CXCL12 can support the production of red blood cells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. Learn more in @SciSignal: scim.ag/4kTxFZz

📢Looking forward to our next CRC 1123 🎓Graduate School Lecture by Florian Gärtner next week Universität München on Mechanisms of 3D Cell Migration ipek-research.com/scrivito/news-… DFG public | @[email protected] Sabine_Steffens