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Nonsense! Engineered tRNAs Offer Universal Solutions to Stop Codon Diseases Driven by her son’s Duchenne diagnosis, Alltrna CEO Michelle Werner is developing drugs that restore protein function across #rarediseases Alltrna #DMD #transferRNA hubs.li/Q03rMktH0

Ultra-Fast Generation of Human Microglia in a Dish May Accelerate Brain Research Traditional #microglia protocols take up to five weeks and often yield immature cells—this approach may improve on both Wyss Institute Harvard Medical School #iPSCs #drugdiscovery hubs.li/Q03rXS4K0

Precision Drug Combination Achieves 88% Response in Older Leukemia Patients A drug combination has shown high response and #remission rates in patients 60 years and older newly diagnosed with #AML Joshua Zeidner MD UNC Lineberger UNC School of Medicine #clinicaltrial hubs.li/Q03s4KMr0

Top Trends Driving Priorities for Companion Diagnostics Development CDx are no longer niche tests but critical levers in the success or failure of targeted therapies. #Pharma companies will need to adapt quickly. Sponsored by Agilent Technologies #DrugDevlopment hubs.li/Q03s1tXs0

New Cholesterol-Lowering Strategy Silences PCSK9, Avoiding Statin Side Effects Inhibiting #PCSK9 gene expression increases #LDL receptor levels on cells surfaces, which promotes #cholesterol uptake from the bloodstream Universitat de Barcelona University of Oregon News hubs.li/Q03s4Rdg0

Genetically Targeting Natural Killer Cells to Fight Cancer Switching off ARIH2 and UBE2F in #NKcells makes them more sensitive to IL-15, allowing the NK cells to attack and kill #tumor cells Monash University oNKo-innate #cancertherapy hubs.li/Q03s4PJ80

Peanut Antibody Discovery Offers Allergy Hope New findings reveal a genetic basis for #peanutallergies, opening the door to large-scale therapeutic interventions Sarita Patil, MD MassGeneral News #antibodies hubs.li/Q03s4RNR0

EGFR Inhibitors Could Be Effective Treatment for NF1 Melanoma Subtype The research builds on prior knowledge that #NF1 acts as a tumor suppressor by negatively regulating RAS signaling pathways NYU Langone Health Perlmutter Cancer Center at NYU Langone Health #EGFRinhibitors #melanoma hubs.li/Q03rMMKM0

Asbestos-Related Mesothelioma Shows Distinct Gene Expression Profile Despite significant cancer treatment advances, people with malignant pleural #mesothelioma have a median survival of up to 18 months Antonio Giordano MD PhD/SHRO #asbestos #geneexpression hubs.li/Q03rMPRW0

One-Time Treatment Rejuvenates Aging Muscle Stem Cells A single dose of PGE2 rejuvenates muscle stem cells in aging mice, offering new hope for tackling #sarcopenia and frailty Sanford Burnham Prebys Stanford University #aging #regenerativemedicine hubs.li/Q03s4VNJ0

Fresh Evidence that Microplastics Raise Colorectal Cancer Risk #Colorectalcancer is the third most common type of cancer diagnosed, and it has been increasing in frequency among young people #WenPan #microplastics hubs.li/Q03rRn4R0

Targeting CDK12: New Mouse Models Illuminate Path to Treat Aggressive Ovarian Cancer CDK12 loss is shown to drive aggressive tumors—and dual CDK12/13 degradation may offer a promising therapeutic strategy University of Michigan #ovariancancer #biomarkers #genetargeting hubs.li/Q03rRpyG0

HPV Linked to Rare Nasal Cancers, Offers Treatment Options The study identified common mutations in these HPV-associated SNSCCs that could be treated by a combination therapies Johns Hopkins Medicine Johns Hopkins Kimmel Cancer Center #HPV #nasalcancer hubs.li/Q03r_N-d0

DeepHeme Algorithm Classifies Bone Marrow Cells with Expert Accuracy The DeepHeme algorithm could speed up the diagnosis of #bloodcancers and drive forward the next generation of AI-informed biomarkers Greg Goldgof Memorial Sloan Kettering Cancer Center #bonemarrow #AI hubs.li/Q03s0wZX0

Our Unique Breathing Patterns Could Offer Insights into Our Health A lightweight wearable device was developed that can continuously track nasal airflow through soft tubes placed under the nostrils WORG: Weizmann Olfaction Research Group Weizmann Institute #breathing #diagnostics hubs.li/Q03s0KHL0

Best Kept Secret-Ome: Juvena Therapeutics and Eli Lilly and Company Partner on Muscle Health Hanadie Yousef, PhD, #JuvenaTherapeutics CEO and co-founder, explains the novel AI-enabled screening platform for secreted signaling proteins fueling #drugdiscovery #AI hubs.li/Q03s1jZT0

Founder’s Nonprofit TTAM to Acquire 23andMe in Surprise Turnaround 23andMe will be acquired by a nonprofit, set up by company co-founder Anne Wojcicki, outbidding Regeneron in a sale of the company's assets Anne Wojcicki #genetictesting #geneticdata hubs.li/Q03sfwfs0

New AI Method Can Detect the Tiniest Traces of Cancer in Blood Samples A new #AI method can detect even the tiniest traces of #tumorDNA in blood samples, helping doctors track if a #cancertreatment is working Anders J. Skanderup Yue Wan A*STAR Genome Institute of Singapore (A*STAR GIS) National Cancer Centre Singapore hubs.li/Q03sfGgK0

Viral Protein Discovery: New Target for Improved COVID-19 Treatments The nonstructural protein 15 (nsp15) enables the SARS-CoV-2 to replicate while suppressing innate antiviral defenses Saeed Lab Boston U Chobanian & Avedisian School of Medicine Boston University #COVID19 #immunesystem #viralprotein hubs.li/Q03sfTWg0

Racial Disparity in Metastasis Biomarker Highlights the Need for Cohort Diversity Significant differences between Black and White #cancer patients have been found in a collagen-based biomarker to predict #metastasis University of Rochester UR Medicine #diagnosticbiomarker hubs.li/Q03sg1Wp0