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Thrilled to be part of this amazing collaboration exploring the conformational space and structural dynamics of heterogeneous RNAs - Yun-Tzai Cloud Lee Maximilia Degenhardt Yun-Xing Wang Lab Jinwei Zhang Lab. Excited to see our work published in nature just in time for the holidays!

How can we determine the structures of highly flexible RNA molecules that exist in multiple conformational states? nature National Cancer Institute "Determining structures of RNA conformers using AFM and deep neural networks" • A major challenge in RNA structural biology is that many

How does RNA's structural flexibility allow it to perform diverse biological functions while maintaining precision in its catalytic activities? "The conformational space of RNase P RNA in solution"nature National Cancer Institute • A groundbreaking study reveals the first direct visualization

A must read for the New Year!!Glad to be part of it!Congratulations to all the authors and friends!!🍾🍾🍾

🔬 Decoding Silencing: How Heterochromatin Transcribes to Silence Itself! 🧬Our latest research reveals how a pioneer transcription factor-like complex PhpC/NF-Y infiltrates repressive heterochromatin, generating transcripts with hidden introns that kickstart RNAi-mediated

Online Now: Structural basis of 5′ splice site recognition by the minor spliceosome dlvr.it/THLDnx

A new paper from Claudia Höbartner and Universität Würzburg #UniWürzburg reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity nature.com/articles/s4158…

Single-molecule live-cell RNA imaging with CRISPR–Csm go.nature.com/3EJPKsM

How sturdy are base pairs near the ends of #RNA hairpins? Perhaps not as stable as one might think, esp. when there are bulges near and far. Led by Bou-Nader lab in Nature Communications, we describe complete structures of #HIV #TAR RNA and its dynamic excursions.nature.com/articles/s4146…

How does enterovirus protease specifically recognize its viral RNA genome? Hint: It takes two! Happy to share our publication in Science Advances Structure of coxsackievirus cloverleaf RNA and 3C protease dimer establishes its RNA-binding mechanism shorturl.at/xvrh1

Congrats to everyone on this project! The first 3D structures of a complete and fully functional RNA device that regulates gene expression through inducible and reversible induction with tetracycline. Not to mention 3-A-resolution for a 40 kDa RNA! academic.oup.com/nar/article/53…

Biochemical profiling and structural basis of ADAR1-mediated RNA editing dlvr.it/TJyVBy

I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex. jbc.org/article/S0021-…

New online! Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment bit.ly/3EeUuH8

We are very excited about our latest work, which just came out The EMBO Journal – embopress.org/doi/full/10.10…. The work Malopolska Centre of Biotechnology UJ was driven by Anna Biela and Ting-Yu Lin in collaboration with Janusz Bujnicki and his team IIMCB, Warsaw, Poland…a short🧵

How to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by Bou-Nader lab, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025.0….

SMDesigner automates the generation of mutations to assess predicted secondary structures and functions of conserved RNA structures based on sequence alignments. #ncRNA #RNA structure Institut national de la recherche scientifique bit.ly/3Fl7yet

New online! Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo bit.ly/4dUN3Cm

The eukaryotic tRNA chaperone La impacts tRNA modification levels (queuosine and others). Interesting because in procaryotes, tRNA modif enzymes themselves are thought to be chaperones. In both cases, there seems to be a link between modif and chaperones. academic.oup.com/nar/article/53…

In the latest issue! tRNA modifications tune m6A-dependent mRNA decay dlvr.it/TLsm32