📃Bench study presenting a novel passive expiratory flow regulation device. 🫁The device bench tested demonstrated a ⬇️ in peak expiratory flow rate and dissipated energy, compared to ventilation with unregulated expiratory flow. 🔓t.ly/RQFb9 #CriticalCare #FOAMed

Predictive Tools for Hypotension in KRT: ✅8 studies (2873 pts) ✅Best ML model : XGB ✅PPI & HRV also significant ✅ML + clinical indicators can forecast IDH in AKI pts, Further validation is needed 🔓t.ly/lnybW #CriticalCare #AKI #MachineLearning

🔎 Have you seen it? ESICM has a new corporate #identity🎉 Including features like: 🌟A modern #logo 🌐A redesigned #website for clarity & accessibility 🎥Watch our launch video & discover how this evolution shows innovation and progress in our mission to advance #intensivecare

Mitochondrial alterations and sepsis - Review of pathophysiological aspects Mitochondrial assessments in immune cells: ✅ biomarkers for clinical recovery, immunometabolic status, responsiveness to oxygen, vasopressor therapies. 🔓 t.ly/iqIl5 #CriticalCare #FOAMed

💊TCD-ABx in vitro: antibiotics in dialysis solutions help achieve desired plasma levels with both 'up-' or 'down-dialysis' towards the unbound target concentration. ✅An elegant life hack for antibiotic therapy during CVVHD? 🔓t.ly/b-MTy #FOAMed #CriticalCare

In memory of Prof. L. Gattinoni

Caro Luciano, sei stato un’ispirazione e un maestro per tutti noi. Il tuo sapere e la tua umanità rimarranno per sempre con noi.

Our speciality has lost one of its founding giants. An inspiration to us all.

🫀 transplantation, open‑lung vent in CPB, postop 🫁 damage. 🐑 model ✔️ OPENVENT Vt 3 mL/kg , PEEP 8 ✔️ NOVENT group no ventilation ✅ OPENVENT: ⬇️ histological🫁 damage ⬇️shunt ⬇️ DP ⬇️ neutrophil and macrophage infiltrations 🔓t.ly/BWbK1

🚨Intensive Care Medicine Experimental (ICMx) is now ON AIR too! 🎙️Podcast release that you CAN’T MISS 💦 Fluid Management and mechanical ventilation strategies! Listen here 👉 loom.ly/pKO2NiE Read here: t.ly/OSgie Pedro Leme Silva | Mariangela Pellegrini ESICM nicolejuffermans #FOAMed

📃HyperO2-induced ⬆️ in 🧠 tissue pO2 (PbtO2) ✔️Circulating models 🔮 a ⬇️ PO2 ✔️Hb transition relaxed (R) to tense (T) state, driven by deO2 ➡️ pO2 diff. across 🧠 capillaries. ✅ Hb R to T ➡️ for ⬆️ PbtO2 lvls in 🧠 tissue during hyperO2. 🔓 t.ly/NhIIb #FOAMed

Mitochondrial metabolic profiles in DKA ⬇️ cellular O2 consumption vs healthy controls. ✅O2 consumption ⬆️ in cells with thiamine or CoQ10 treatment ✅ Thiamine and CoQ10 could potentially have therapeutic benefits in DKA. #FOAMed #CriticalCare 🔓 t.ly/xDwm1

Renal venous flow patterns in sepsis ✅Proximal (PRVF) and intrarenal venous flow (IRVF) not entirely congruent ✅PRVF ➕IRVF: ⬆️ predictive ability for 28-day renal function prognosis. ✅Early improvement in renal venous congestion is crucial 🔓 t.ly/zkOAW #FOAMed

Effects of FCV using negative end-expiratory pressures (NEEP), on 🧠 hemodynamics in a 🐖 model of intracranial hypertension. ✅ FCV➕ NEEP appears to be safe ✅ additional tool for severe intracranial pressure episodes. 🔓t.ly/hBF7q #FOAMed #CriticalCare

📃Modulation of β3-AR in an  🐀 model of resuscitated septic shock ✅β3-AR is resistant to desensitization ✅its inhibition improves cardiac and vascular function without affecting the short-term survival. 🔓t.ly/SCq-I

RescueDoppler, a continuous hands-free carotid Doppler system in a 🐖 model of 🫀 arrest. ✅expected sensitivity of 98% identifying spontaneous circulation during both manual and mechanical chest compressions. 🔓 t.ly/knEtu #FOAMEed #CriticalCare

🤖Potential of ML models in predicting patient discharge readiness. ✅👨‍⚕️behavior closely mirrored ✅eligible patients earlier identified ✅ Promising screening tool ✅ more efficient reliable decision-making. 🔓📃 t.ly/ZPCpG #AI #MachineLearning #ICU #Innovation

E.Coli 🐖 sepsis model , shows the time course of neutrophil distribution using  PET-tracer [11C]NES targeting Neutrophil Elastase. Neutrophils+neutrophil elastase : ✅important in sepsis ✅blocking➡️ future treatment in selected situations. 🔓 t.ly/_L8OS

Wearable devices as a game-changer. New strategies for continuous monitoring in acute medicine & critical care. ✅ Less invasive ✅ Better ICU-to-ward transition ✅ Delirium & pressure injury detection Read our paper pubmed.ncbi.nlm.nih.gov/40016479/ #WearableDevices #ICU #MedTech #AI #WD

Do the IV fluids we provide to our critically ill patients trash the glycocalyx? This systematic review tackles this issue as we always try to balance benefit and harm. Another example where less could be more. 🎩 tip to the authors! eddyjoemd.com/foamed/