Led by Dr. Harry Horsnell (hlhorsnell), researchers in the Dr Sophie Acton at @UCL find that in murine models of immune challenge, cytoskeletal mechanics of a cellular meshwork of fibroblasts determine tissue tension independently of #ECM scaffolds. 🔗 go.nature.com/3zwVsJw

Acton and colleagues examine the mechanics of lymph node swelling during immune responses. Tissue tension regulates FRC proliferation and PDPN–CLEC-2 signaling regulates this process, which in turn regulates T cell activation. See rdcu.be/cTlWf & doi.org/10.1038/s41590…

Congratulations Sophie!

Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function biorxiv.org/cgi/content/sh… #biorxiv_immuno

#Preprint Latest work from super postdoc Dr Spiros Makris is now online bioRxiv Immunology We conditionally deleted #podoplanin in adult lymphoid tissues and found serious defects in homeostatic tissue organisation and fibroblastic reticular cell function doi.org/10.1101/2022.1…

Lucas presented his poster yesterday! #BSI22 Lucas is a med student who worked with hlhorsnell to address reviewers comments for his publication… “Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics” doi.org/10.1038/s41590…

An awesome stromal workshop is coming to Melbourne Friday 17th March! Featuring Burkhard Ludewig, Mariapia Degli-Esposti, Mark Coles & Rod Dunbar. Its going to be ace! #Stroma4life Register and submit an abstract here --> immunology.org.au/events/ASI-Str…

Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By HongchengMAI Jie Luo biorxiv.org/content/10.110… 🧵👇🏼(turn on the sound)

Bravo Henry De Belly and colleagues! Beautiful data and opto-gentics methods, foundational work on cell membrane tension propagation. Now to figure out cell to cell/in vivo rules?!? #lasersforever #cellmechanics

Great couple of days at Yarra valley lodge soaking in all things immunology and meeting the #IgV2023 community! Made great connections. Thanks Australian and New Zealand Society for Immunology #IgV for the oral presentation award, a nice surprise to end the week #Immunology #lymphnodes

Congratulations to Sapna Devi for receiving the 2023 Daniel Rechtman Research Award by The CASS Foundation to support her research on the impact of stress signals on anti-#tumour #immunity. doherty.edu.au/news-events/ne… UniMelb MDHS @theRMH Scott Mueller

Fibroblasts rule! Extending work in the spleen we find SpiB TF controls FRC function and anti viral immunity in the lymph node. Thanks Yannick Alexandre & Scott Mueller for the team effort to get my first author postdoc paper out. Stay tuned for more fibroblast discoveries #frc4life

💫Check out this month's ICB - the journal highlight from hlhorsnell Scott Mueller Yannick Alexandre and colleagues - The transcription factor SpiB regulates the fibroblastic reticular cell network and CD8+ T-cell responses in lymph nodes. onlinelibrary.wiley.com/doi/10.1111/im…

Looking forward to the upcoming mesenchymal international Aegean Conferences! If you consider yourself an Early Career Researcher (ECR) please come along to our first ever ECR specific session on Saturday 29th June 3-5pm. Its going to be a fun time bringing ECRs together #stroma4life