Bob Wachter In our outpatient mAb/anti-viral clinic in San Diego we’ve seen this 5 times (~2% of Paxlovid pts thus far). Definitely real, but seems mild, with more implications for isolation/infection control than real morbidity. Agree shouldn’t distract from otherwise great efficacy.

It's really striking how well trained scent dogs can detect Covid (and #LongCovid): a randomized controlled, triple-blinded validation trial and real life study at in airport. They need to get retrained for diff't variants globalhealth.bmj.com/lookup/doi/10.… BMJ Global Health Medicine and Health, University of Helsinki

I developed Covid symptoms and tested positive Wed By Sat, I felt fantastic Today, I feel like death. If I were eligible for Paxlovid, would have finished yesterday. Be cautious of rebound symptom data— reporting bias is strong, my N=1 tells me it happens w/o treatment too :)

SF folks: it's now a big-time surge. No longer just cases (~500/d reported, so true # >2K, or ~250/100K/d). Also major uptick in hospitalizations: 98 in SF (vs 18 six wks ago). UCSF Health 41 pts in hospital, twice April #. If you're trying to stay well, time to up your game.

Ron Desantis Yale Class ‘01 Brett Kavanaugh Yale Class ‘87 Clarence Thomas Yale Class ‘74 Peter Hotez Yale Class ‘80 For years after graduation I worried maybe I should have spent less time in the laboratory in college, gotten out more? Maybe not a bad decision after all…

Nothing I can say that's not in the fantastic early reviews but it's a fun, surprising and beautiful quick read. The book of the summer. On the fence? Watch the trailer: katiehafner.com/books-new/the-…

Bebtelovimab is the only monoclonal antibody left that works against BA.5. The US government supply is about to run out. wsj.com/articles/eli-l… Stephanie Armour Peter Loftus

Orchid Mantis. 🌷🦗🌸

Yikes! And the recently-approved UK Moderna booster is different so we can't borrow data this time around. Are there other customers lined up for the US booster version?

NNT = 15.3 [10.9 - infinite]. Same ballpark as we've seen. Remains possible there are different consequences wrt long covid, etc, but encouraging that tx is worth prescribing even in lower risk pops. (Works out to ~67 thousand ER visits saved per million doses to vax folks.)

Congrats Ziyang Zhang! A rockstar chemist and a fantastic communicator.

4/n Make no mistake: the 4th CoV is coming. Our labs are doing our part to modify our Covid vaccine to develop a universal CoV vaccine. Meanwhile the GOP Senate wants to keep throwing out distractions and do its part to condemn the American people to future pandemics

This may be one of the most exciting and comprehensive reviews on mitochondria I've seen in a long, long time. "Mitochondrial signal transduction", Picard and Shirihai cell.com/cell-metabolis…

Love this, I'm gonna need to copy that ACP note

BBC Statement on Ed Lawrence

Very interesting if true. One meter is closer than I get to most strangers in a park unless it's very crowded, but would certainly have import for things like music festivals, sports events. But if true, shouldn't we have already seen this signature eg at football games?

The first patient has been dosed with AB-1015 in a Phase 1, first-in-human clinical trial for patients with ovarian cancer that is resistant to platinum-based regimens. It is our first internally discovered T cell medicine to enter clinical development: shorturl.at/iwT03

Celebrating this weekend's marriage of my daughter Zoë Lyon, MD to Joe Hiatt – both special people who live life with passion, compassion & joy. Amazing (& warm) evening w/ family & friends (incl. their co-UCSF IM Chiefs residents) @ Conservatory of Flowers in Golden Gate Park.